methyl 5-methoxy-2-(4-methoxybenzyl)benzoate | 1431377-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 5-methoxy-2-(4-methoxybenzyl)benzoate
• 英文别名: methyl 5-methoxy-2-[(4-methoxyphenyl)methyl]benzoate
• CAS: 1431377-48-8
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.328
• InChiKey: FCLJMMIQAXWOGX-UHFFFAOYSA-N

物化性质

• 沸点：
  427.4±40.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 5-methoxy-2-(4-methoxybenzyl)benzoate 在 咪唑 、 lithium chloro-isopropyl-magnesium chloride 、 三溴化硼 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes

  摘要：

  Fluorogenic molecules are important tools for advanced biochemical and biological experiments. The extant collection of fluorogenic probes is incomplete, however, leaving regions of the electromagnetic spectrum unutilized. Here, we synthesize green excited fluorescent and fluorogenic analogues of the classic fluorescein and rhodamine 110 fluorophores by replacement of the xanthene oxygen with a quaternary carbon. These anthracenyl "carbofluorescein" and "carborhodamine 110" fluorophores exhibit excellent fluorescent properties and can be masked with enzyme- and photolabile groups to prepare high-contrast fluorogenic molecules useful for live cell imaging experiments and super-resolution microscopy. Our divergent approach to these red-shifted dye scaffolds will enable the preparation of numerous novel fluorogenic probes with high biological utility.

  DOI：

  10.1021/cb4000822
• 作为产物：
  描述：

  4-甲氧基苯甲醛 在 1,1'-双(二苯基膦)二茂铁 、 palladium diacetate 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 methyl 5-methoxy-2-(4-methoxybenzyl)benzoate
  参考文献：
  名称：

  钯催化的邻溴苯甲醛，N-甲苯磺酰hydr和甲醇的三组分偶联反应。

  摘要：

  描述了由配体控制的钯催化的邻溴苯甲醛，N-甲苯磺酰and和甲醇的三组分反应。该反应使用容易获得的化合物作为起始原料，同时显示出广泛的底物范围和良好的官能团相容性。

  DOI：

  10.1021/acs.orglett.0c00579

文献信息

• Rhodamines with a Chloronicotinic Acid Fragment for Live Cell Superresolution STED Microscopy**
  作者：Florian Grimm、Jasmin Rehman、Stefan Stoldt、Taukeer A. Khan、Jan Gero Schlötel、Shamil Nizamov、Michael John、Vladimir N. Belov、Stefan W. Hell

  DOI：10.1002/chem.202005134

  日期：2021.4

  fluorescent dye with a 2,6‐dichloro‐5‐R‐nicotinic acid residues (R=H, F). The following reaction with thioglycolic acid is selective, involves only one chlorine atom at the carbon between pyridine nitrogen and the carboxylic acid group and affords new rhodamine dyes absorbing at 564/ 573 nm and emitting at 584/ 597 nm (R=H/ F, in aq. PBS). Conjugates of the dyes with “small molecules” provided specific

  2,6-二氯-5- R-烟酸在 C-4 处甲酰化，然后与 3-羟基-N , N-二甲基苯胺缩合，得到流行的 TAMRA 荧光染料与 2,6-二氯-5-R 的类似物‐烟酸残基（R=H，F）。以下与巯基乙酸的反应是选择性的，仅涉及吡啶氮和羧酸基团之间的碳上的一个氯原子，并提供新的罗丹明染料，在 564/ 573 nm 处吸收并在 584/ 597 nm 处发射（R=H/ F， PBS 水溶液中）。染料与“小分子”的结合物为活细胞中的细胞器以及细胞骨架成分提供了特异性标记（共价和非共价），并与由610CP和SiR染料制备的荧光探针结合并应用于双色使用 775 nm STED 激光的 STED 显微镜。
• Turning Red without Feeling Embarrassed─Xanthenium-Based Photocages for Red-Light-Activated Phototherapeutics
  作者：Alexandra Egyed、Krisztina Németh、Tibor Á. Molnár、Mihály Kállay、Péter Kele、Márton Bojtár

  DOI：10.1021/jacs.2c11499

  日期：——

  properties of a carboxanthenium derivative were further evaluated in the context of light-controlled drug release using a camptothecin-derived chemotherapeutic drug, SN38. Notably, the caged drug showed orders of magnitude lower efficiency in cellulo, which was reinstated after red light irradiation. The presented photocages offer properties that facilitate the translation of photoactivated chemotherapy

  在此，我们提出了一组高产、简洁的途径，获得一组钇衍生的、水溶性的、低分子量的光笼，允许在绿色到红色区域进行光控货物释放。非常重要的是，即使在合成的最后阶段，这些新的光笼也允许通过酯、氨基甲酸酯或碳酸酯键安装各种有效负载。在绿光、橙光或红光照射下，有效载荷被高效释放，导致羧酸、酚类和胺类的释放。使用喜树碱衍生的化疗药物 SN38 在光控药物释放的背景下进一步评估了碳蒽衍生物近乎理想的特性。值得注意的是，笼中药物在纤维素中的效率降低了几个数量级，但在红光照射后又恢复了。所提出的光笼提供了促进光活化化疗转化为临床应用的特性。
• COLOR CONVERSION WITH SOLID MATRIX FILMS
  申请人：StoreDot Ltd.

  公开号：US20180037738A1

  公开（公告）日：2018-02-08

  This invention is directed to photoluminescent compounds based on rhodamine dyes with green or red emission and uses thereof for photoluminescence based devices.
• CONTROL OF ILLUMINATION SPECTRA FOR LCD DISPLAYS
  申请人：StoreDot Ltd.

  公开号：US20180039131A1

  公开（公告）日：2018-02-08

  Color conversion films for a LCD (liquid crystal display) having RGB (red, green, blue) color filters, as well as such displays, formulations, precursors and methods are provided, which improve display performances with respect to color gamut, energy efficiency, materials and costs. The color conversion films absorb backlight illumination and convert the energy to green and/or red emission at high efficiency, specified wavelength ranges and narrow emission peaks. Film integration and display configurations further enhance the display performance with color conversion films utilizing various color conversion elements and possibly patterned and/or integrated with a crosstalk blocking matrix. For example, color conversion and/or assistant dyes may be used to enhance spectral regions transmitted through the color filters and shape the illumination spectrum, to improve efficiency and performance.
• MODIFICATIONS OF THE SOL-GEL AND PROCESS THEREOF
  申请人：StoreDot Ltd.

  公开号：US20180072892A1

  公开（公告）日：2018-03-15

  Color conversion films for a LCD (liquid crystal display) having RGB (red, green, blue) color filters, as well as such displays, formulations, precursors and methods are provided, which improve display performances with respect to color gamut, energy efficiency, materials and costs. The color conversion films absorb backlight illumination and convert the energy to green and/or red emission at high efficiency, specified wavelength ranges and narrow emission peaks. The color conversion films may comprise at least one of: polydimethylsiloxane hydroxy terminated, dendritic polyol or polyvinylpyrrolidone.