(E)-tert-butyl 2-(quinolin-3-ylmethylene)hydrazinecarboxylate | 106869-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-tert-butyl 2-(quinolin-3-ylmethylene)hydrazinecarboxylate
• 英文别名: tert-butyl N-[(E)-quinolin-3-ylmethylideneamino]carbamate
• CAS: 106869-44-7
• 化学式: C₁₅H₁₇N₃O₂
• 分子量: 271.319
• InChiKey: KUZOARIZCDBIAU-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.58
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  3-喹啉甲醛 、 肼基甲酸叔丁酯 反应 1.0h， 以100%的产率得到(E)-tert-butyl 2-(quinolin-3-ylmethylene)hydrazinecarboxylate
  参考文献：
  名称：

  Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

  摘要：

  A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.056