ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside | 1240408-09-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside
• CAS: 1240408-09-6
• 化学式: C₆₂H₆₄O₁₆SSi
• 分子量: 1125.33
• InChiKey: PGHRXTYRRXSQJQ-AEASFNJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.58
• 重原子数：
  80.0
• 可旋转键数：
  20.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  194.72
• 氢给体数：
  0.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  3-(trifluoroacetamido)propyl 3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->2)-3,4,6-tri-O-benzyl-α-D-mannopyranoside 、 ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以70%的产率得到3-trifluoroacetamidopropyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-α-D-mannopyranosyl-(1->2)-3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->2)-3,4,6-tri-O-benzyl-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis of 3,6-branched oligomannoside fragments of the mannan from Candida albicans cell wall corresponding to the antigenic factor 4

  摘要：

  3-Aminopropyl glycosides of 3,6-branched penta- and hexamannoside fragments of the cell wall mannan from Candida albicans, corresponding to the antigenic factor 4, have been synthesized. Subsequent coupling of both oligosaccharides with BSA using the squarate procedure provided corresponding neoglycoconjugates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.11.012
• 作为产物：
  描述：

  2,3,4,6-Tetra-O-benzoyl-α-D-mannopyranosyl bromide 、 ethyl 2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1-thio-6-O-trityl-α-D-mannopyranoside 在 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以73%的产率得到ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1-thio-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis of 3,6-branched oligomannoside fragments of the mannan from Candida albicans cell wall corresponding to the antigenic factor 4

  摘要：

  3-Aminopropyl glycosides of 3,6-branched penta- and hexamannoside fragments of the cell wall mannan from Candida albicans, corresponding to the antigenic factor 4, have been synthesized. Subsequent coupling of both oligosaccharides with BSA using the squarate procedure provided corresponding neoglycoconjugates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.11.012