(7'R,8'S,7''R,8''S)-erythro-strebluslignanol G | 1427279-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (7'R,8'S,7''R,8''S)-erythro-strebluslignanol G
• 英文别名: (7'R,8'S,7"R,8"S)-erythro-strebluslignanol G；(1R,2S)-1-[17-[(1R,2S)-1,2-dihydroxypropyl]-12,25-bis(prop-2-enyl)-8,21-dioxapentacyclo[20.4.0.02,7.09,14.015,20]hexacosa-1(22),2(7),3,5,9(14),10,12,15(20),16,18,23,25-dodecaen-4-yl]propane-1,2-diol
• CAS: 1427279-40-0
• 化学式: C₃₆H₃₆O₆
• 分子量: 564.678
• InChiKey: IGIPGPRQIZBOFQ-FYQGPRJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (7'R,8'S,7''R,8''S)-erythro-strebluslignanol G 、 乙酸酐 在 吡啶 、 potassium acetate 作用下， 以4 mg的产率得到tetraacetyl strebluslignanol G
  参考文献：
  名称：

  Anti-hepatitis B virus lignans from the root of Streblus asper

  摘要：

  Four new lignans, strebluslignanol F (1), (7'R,8'S,7 '' R,8 '' S)-erythro-strebluslignanol G (2), isomagnaldehyde (3) and isostrebluslignanaldehyde (4), along with 12 known lignans (5-16) were isolated from the ethyl acetate-soluble part of MeOH extract of the root of Streblus asper. Their structures were elucidated through various spectroscopic methods, including 1D NMR (H-1 NMR, C-13 NMR), 2D NMR (HMQC, HMBC and NOESY) and HRMS. The stereochemistry at the chiral centers was determined using CD spectra, as well as analyses of coupling constants and optical rotation data. The isolated lignans were evaluated for their anti-HBV activities in vitro using the HBV transfected HepG2.2.15 cell line. The most active lignans, (7'R,8'S,7 '' R,8 '' S)-erythro-strebluslignanol G, magnolol, isomagnolol and isolariciresinol, exhibited significant anti-HBV activities with IC50 values of 1.58, 2.03, 10.34 and 3.67 mu M, respectively, for HBsAg with no cytotoxicity, and of 3.24, 3.76, 8.83 and 14.67 mu M, respectively, for HBeAg with no cytotoxicity. (7'R,8'S,7 '' R,8 '' S)-erythro-Strebluslignanol G and magnolol showed significant anti-HBV activities to inhibit the replication of HBV DNA with the IC50 values of 9.02 and 8.67 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.046