7-[(E)-2-(phenyl)vinyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridine | 65964-12-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-[(E)-2-(phenyl)vinyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridine
• 英文别名: 2-(4-chloro-phenyl)-7-styryl-imidazo[1,2-a]pyridine；2-(4-chlorophenyl)-7-[(E)-2-phenylethenyl]imidazo[1,2-a]pyridine
• CAS: 65964-12-7
• 化学式: C₂₁H₁₅ClN₂
• 分子量: 330.816
• InChiKey: ROBSYJFLTOLFFQ-VOTSOKGWSA-N

物化性质

• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基吡啶 在 potassium tert-butylate 、 碳酸氢钠 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 7-[(E)-2-(phenyl)vinyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Arylstyrylimidazo[1,2-a]pyridine-based donor–acceptor acidochromic fluorophores: Synthesis, photophysical, thermal and biological properties

  摘要：

  A series of new fluorescent arylstyrylimidazo[1,2-a]pyridines was synthesized and fully characterized. It is observed that the E isomers are stable in the solid state and in solutions. The absorption and emission properties of the compounds changed drastically upon acidification. The compounds showed good thermal stability for practical applications. In addition, antimicrobial, antioxidant, and DNA-cleavage activity of the compounds were examined. The results indicate that the compounds did not show any antimicrobial and antioxidant activity. However, they caused decreased mobility of form I DNA and also showed DNA cleavage activity. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2015.05.030