kmg-NB5-13C | 1350622-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: kmg-NB5-13C
• 英文别名: 2,4-dimethoxy-7H,8H,9H,4-thiazepino[7',6'-5,4]thiopheno[3,2-d]pyrimidin-6-one；4,6-Dimethoxy-8,14-dithia-3,5,11-triazatricyclo[7.5.0.02,7]tetradeca-1(9),2(7),3,5-tetraen-10-one
• CAS: 1350622-77-3
• 化学式: C₁₁H₁₁N₃O₃S₂
• 分子量: 297.359
• InChiKey: UIGSCNZVHMZBSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PROTEIN KINASE D INHIBITORS
  申请人：Wipf Peter

  公开号：US20140045821A1

  公开（公告）日：2014-02-13

  Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.

  根据式(I)，化合物是蛋白激酶D(pan-PKD)活性的有效抑制剂。PKD控制着细胞中的关键信号级联，影响细胞增殖、基因转录和蛋白质运输。因此，这些创新化合物的药学合适组合物是治疗PKD活性改变引起的病理情况的候选药物。
• US9840515B2
  申请人：——

  公开号：US9840515B2

  公开（公告）日：2017-12-12
• [EN] PROTEIN KINASE D INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTÉINE KINASE D
  申请人：UNIV PITTSBURGH

  公开号：WO2012078859A2

  公开（公告）日：2012-06-14

  Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.