1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one | 1186004-10-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one
• 英文别名: 1-(2-hydroxyphenyl)-3-pyridin-4-ylpropan-1-one
• CAS: 1186004-10-3
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: NWIXWMAPTKKLID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(溴甲基)吡啶氢溴酸盐 在 盐酸 、 aluminum (III) chloride 、 sodium methylate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 potassium hydroxide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 29.17h， 生成 1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one
  参考文献：
  名称：

  Rafi, Shaik; Kandagatla, Bhaskar; Darapaneni, Balachennaiah, Indian Journal of Heterocyclic Chemistry, 2015, vol. 24, # 4, p. 459 - 464

  摘要：

  DOI：

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Vinylpyridines as Building Blocks for the Photocatalyzed Synthesis of Alkylpyridines
  作者：Luca Capaldo、Maurizio Fagnoni、Davide Ravelli

  DOI：10.1002/chem.201701346

  日期：2017.5.11

  The photocatalyzed addition of several hydrogen donors (ethers, aldehydes, alkanes, amides) onto vinylpyridines was achieved. This approach provided access to alkylpyridines, which are important building blocks for the preparation of compounds with biological activity. The strategy was very simple and straightforward because it required only a small amount of a cheap decatungstate salt as photocatalyst

  实现了几种氢供体（醚，醛，烷烃，酰胺）的光催化加成到乙烯基吡啶上。这种方法提供了对烷基吡啶的访问，烷基吡啶是制备具有生物活性的化合物的重要组成部分。该策略非常简单明了，因为它只需要少量廉价的廉价的癸二酸盐作为光催化剂。作为附加的优点，该反应可以在阳光照射下以及在流动条件下进行。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• FLAVOR MOLECULES
  申请人：Daniher Andrew

  公开号：US20100040753A1

  公开（公告）日：2010-02-18

  A method of providing a range of flavors to an orally-receivable or ingestible product, the method including adding at least one compound, including salts thereof, of the formula: wherein R 1 may be H, OH, O(CH 2 ) 2 OH, OCH 2 OCH 3 or R 2 may be selected from a range of 5- and 6-membered heterocyclic rings, and wherein R 3 may be H or OH. The compounds give rise to a wide range of flavors, and some are useful as sweetness enhancers, this allowing sweetener content to be reduced while maintaining sweetness. Also disclosed are orally-receivable or ingestible products including the compounds.

  一种为口腔可接受或可摄入产品提供一系列口味的方法，该方法包括添加至少一种化合物，其包括以下式子的盐：其中R1可以是H，OH，O（CH2）2OH，O OCH3或R2可以从5-和6-成员杂环环中选择，其中R3可以是H或OH。这些化合物产生广泛的口味，其中一些化合物可用作甜味增强剂，从而可以减少甜味剂含量而保持甜味。还公开了包含这些化合物的口腔可接受或可摄入产品。
• Flavor Molecules
  申请人：DANIHER Andrew

  公开号：US20100272656A1

  公开（公告）日：2010-10-28

  A method of providing a range of flavors to an orally-receivable or ingestible product, the method including adding at least one compound, including salts thereof, of the formula: wherein R 1 may be H, OH, O(CH 2) 2 OH, OCH 2 OCH 3 or R 2 may be selected from a range of 5- and 6-membered heterocyclic rings, and wherein R 3 may be H or OH. The compounds give rise to a wide range of flavors, and some are useful as sweetness enhancers, this allowing sweetener content to be reduced while maintaining sweetness. Also disclosed are orally-receivable or ingestible products including the compounds.

  一种为口服或摄入产品提供一系列口味的方法，该方法包括添加至少一种化合物，其包括上述公式中的盐：其中R1可以是H、OH、O(CH2)2OH、O OCH3或；R2可以从5-和6-成员杂环环中选择，其中R3可以是H或OH。这些化合物产生广泛的口味，其中一些有助于增强甜味，从而可以在保持甜味的同时减少甜味剂含量。此外，还披露了包括这些化合物的口服或摄入产品。