(E)-3-(3-Chloro-phenyl)-1-naphthalen-1-yl-propenone | 38132-50-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-(3-Chloro-phenyl)-1-naphthalen-1-yl-propenone
• 英文别名: 3-(3-chlorophenyl)-1-naphthalen-1-ylprop-2-en-1-one
• CAS: 38132-50-2
• 化学式: C₁₉H₁₃ClO
• 分子量: 292.765
• InChiKey: WCUPRNSNUQNKEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-3-(3-Chloro-phenyl)-1-naphthalen-1-yl-propenone 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 二甲基亚砜 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 16.0h， 以55%的产率得到2-(4-(1-naphthoyl)-2,5-bis(3-chlorophenyl)-1,3-dithiol-2-yl)-1-(naphthalen-1-yl)ethan-1-one
  参考文献：
  名称：

  室温条件下，用元素硫二聚硫化查尔酮来合成四取代的1,3-二硫醇。

  摘要：

  发现查尔酮与元素硫发生硫化二聚反应，生成四取代的1,3-二硫醇。发现反应在室温下在DMSO中在氮基催化剂存在下进行。

  DOI：

  10.1021/acs.joc.0c01618
• 作为产物：
  描述：

  萘 在 sodium hydroxide 、 三氯化铝 作用下， 以 四氯化碳 、 乙醇 为溶剂， 反应 2.5h， 生成 (E)-3-(3-Chloro-phenyl)-1-naphthalen-1-yl-propenone
  参考文献：
  名称：

  Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines

  摘要：

  A series of 2-amino-4-(1 -naphthyl)-6-arylpyrimidines have been synthesized and characterized by IR, NMR, MS, elemental analyses and evaluated for in vitro antibacterial and antifungal activities. Some of the compounds were found to be active against a limited panel of bacteria and fungi. In particular, compounds 4b and 4e were found to be the most effective analogs against the tested bacterial and fungal strains. (c) 2006 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.09.012

文献信息

• SOLID SiO2-H3PO4 IS AN EFFICIENT CATALYST FOR CYCLIZATION OF ENONES UNDER SOLVENT-FREE CONDITION: SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME OXAZINE DERIVATIVES
  作者：GANESAMOORTHY THIRUNARAYAN、VELAYUTHAM RENUKA

  DOI：10.4067/s0717-97072014000300011

  日期：——

  A series of some 1, 3-oxazine amine derivatives including 4-(1-naphthyl)-5,6-dihydro-6-(substituted phenyl)-oxazine-2-amines has been synthesised by lsolid SiO2-H3PO4 catalyzed solvent-free cyclization of aryl chalcones and urea under microwave irradiation. The yields of the oxazines were more than 80%. The synthesised oxazine amines were characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these oxazine derivatives have been studied using Bauer-Kirby method.