| 251348-10-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 251348-10-4
• 化学式: C₁₀₀H₁₁₃NO₂₄
• 分子量: 1712.99
• InChiKey: VXDNTBXQOWZOSC-IDUCWGHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.88
• 重原子数：
  125.0
• 可旋转键数：
  45.0
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  278.12
• 氢给体数：
  2.0
• 氢受体数：
  24.0

反应信息

• 作为反应物：
  描述：

  在 乙二胺 作用下， 以 正丁醇 为溶剂， 生成
  参考文献：
  名称：

  Expedient synthesis of a series of N-acetyllactosamines

  摘要：

  A series of poly-N-acetyllactosamines representative of those found on complex N-glycans was synthesized for use in the kinetic characterization of recently cloned glycosyltransferases. The syntheses involved the iterative addition of a selectively protected N-acetyllactosaminyl donor to an octyl alpha-D-mannopyranosyl-1,6-beta-mannopyranoside acceptor, followed by deprotection. In addition, non-reducing galactosyl residues were removed with beta-galactosidase to furnish GlcNAc terminated compounds. In this manner tetra- to octasaccharides were efficiently produced. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00485-0
• 作为产物：
  描述：

  [(2R,3S,4S,5R,6S)-5-acetyloxy-2-(acetyloxymethyl)-4-(2-chloroacetyl)oxy-6-[(2R,3S,4R,5R,6R)-5-(1,3-dioxoisoindol-2-yl)-6-[[(2R,3R,4S,5S,6S)-6-[[(2R,3R,4S,5S,6R)-6-octoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methoxy]-3,4,5-tris(phenylmethoxy)oxan-2-yl]methoxy]-4-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl]oxyoxan-3-yl] 2-chloroacetate 在 2,6-二甲基吡啶 、 硫脲 作用下， 以81%的产率得到
  参考文献：
  名称：

  Expedient synthesis of a series of N-acetyllactosamines

  摘要：

  A series of poly-N-acetyllactosamines representative of those found on complex N-glycans was synthesized for use in the kinetic characterization of recently cloned glycosyltransferases. The syntheses involved the iterative addition of a selectively protected N-acetyllactosaminyl donor to an octyl alpha-D-mannopyranosyl-1,6-beta-mannopyranoside acceptor, followed by deprotection. In addition, non-reducing galactosyl residues were removed with beta-galactosidase to furnish GlcNAc terminated compounds. In this manner tetra- to octasaccharides were efficiently produced. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00485-0