| 1186073-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1186073-83-5
• 化学式: C₃₇H₅₁IN₄O₉S
• 分子量: 854.804
• InChiKey: UBZMZXXLIKWXMH-NYTTUPTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.53
• 重原子数：
  52.0
• 可旋转键数：
  15.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  142.35
• 氢给体数：
  0.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  (E)-(R)-8-[(2S,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-6-methyl-non-7-enoic acid tert-butyl ester 、 在 lithium hexamethyldisilazane 作用下， 以 六甲基磷酰三胺 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 2.17h， 以30%的产率得到
  参考文献：
  名称：

  Total Synthesis of (+)-Sorangicin A

  摘要：

  The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity. Critical to the final-stage success was the use of a carefully defined Stille coupling and a Mukaiyama macrolactonization as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomerization and/or destruction of the delicate (Z,Z,E)-trienoate linkage.

  DOI：

  10.1021/ja906115a
• 作为产物：
  描述：

  在 hexaammonium heptamolybdate tetrahydrate 、 双氧水 作用下， 以 乙醇 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  Total Synthesis of (+)-Sorangicin A

  摘要：

  The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity. Critical to the final-stage success was the use of a carefully defined Stille coupling and a Mukaiyama macrolactonization as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomerization and/or destruction of the delicate (Z,Z,E)-trienoate linkage.

  DOI：

  10.1021/ja906115a