8-Methylquinoline-6-carboxylic acid | 926217-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Methylquinoline-6-carboxylic acid
• CAS: 926217-76-7
• 化学式: C₁₁H₉NO₂
• 分子量: 187.19
• InChiKey: KGSKTDIRLHAAMI-UHFFFAOYSA-N

物化性质

• 沸点：
  358.6±27.0 °C(Predicted)
• 密度：
  1.285±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Methylquinoline-6-carboxylic acid 、 2-Tert-butylspiro[5,7-dihydro-1,3-benzothiazole-6,4'-piperidine]-4-one 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 US20240109915, Example 48
  参考文献：
  名称：

  [EN] NOVEL ACC INHIBITORS
  [FR] NOUVEAUX INHIBITEURS DE L'ACC

  摘要：

  A compound having the structures: Formulae (Ia) or (Ib) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6alkyl, C1-C6alkoxy and -(CH2)m-W, where W is C3-C8cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6alkyl, C1-C6alkoxy, -SO2-R', - CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', - SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6alkyl or C3-C8cycloalkyl; R1selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms selected from the group consisting of N, S and O atoms; and, a 9- or 10-membered bicyclic aryl, heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said phenyl, naphthyl, aryl, heterocyclic, or heteroaryl may be unsubstituted or substituted by halo, cyano, deuterium, hydroxy, C1-C6alkyl, C1-C6alkoxy, phenyl, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R, -SO2NR'R", P(O)R'R", Formula (Ic), or NR'R"' or SR' where R' and R'' are independently H, C1-C6alkyl or C3-C8cycloalkyl; and,mandnare independently 0, 1, 2 or 3. The invention also relates to pharmaceutically acceptable salts of these compounds and to pharmaceutically acceptable solvates thereof; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly acne.

  公开号：

  WO2024023727A1

文献信息

• [EN] ANTIVIRAL HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ANTIVIRAUX
  申请人：ENANTA PHARM INC

  公开号：WO2021066922A1

  公开（公告）日：2021-04-08

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了化合物的结构式（I），或其药学上可接受的盐、酯或前药：这些化合物抑制人类呼吸道合胞病毒（HRSV）或人类甲型流感病毒（HMPV）的抑制剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HRSV或HMPV感染的受试者。该发明还涉及通过给予含有本发明化合物的药物组合物来治疗受试者的HRSV或HMPV感染的方法。