β-<2-Hydroxy-cyclopentyl>-propionsaeure | 18631-66-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-<2-Hydroxy-cyclopentyl>-propionsaeure
• 英文别名: 3-(2-Hydroxycyclopentyl)propanoic acid
• CAS: 18631-66-8
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: MLNMPAZIVJUQLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(2-氧代环戊基)丙酸 在 sodium tetrahydroborate 、 碳酸氢钠 作用下， 生成 β-<2-Hydroxy-cyclopentyl>-propionsaeure
  参考文献：
  名称：

  与多磷酸的有机反应-VIII：与内酯（进一步延伸），羟基酸和酯的分子内酰化

  摘要：

  多磷酸中内酯的分子内酰化作用已扩展为具有角甲基的γ-和δ-内酯。进一步表明，在这种反应中，羟基酸可以方便地代替相应的内酯。该反应也已经应用于简单的酯。

  DOI：

  10.1016/0040-4020(68)88004-4

文献信息

• TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY
  申请人：Gombert Frank

  公开号：US20110312879A1

  公开（公告）日：2011-12-22

  Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, Gly, a glycolic acid residue or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in non-infected individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These depsipeptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
• US8883720B2
  申请人：——

  公开号：US8883720B2

  公开（公告）日：2014-11-11
• [EN] TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY<br/>[FR] PEPTIDOMIMÉTIQUES EN ÉPINGLE À CHEVEUX BÊTA FIXÉS SUR UNE MATRICE PRÉSENTANT UNE ACTIVITÉ D'ANTAGONISME DE CXCR4
  申请人：POLYPHOR AG

  公开号：WO2010060479A1

  公开（公告）日：2010-06-03

  Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, GIy, a glycolic acid residue or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in non-infected individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These depsipeptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.