10,11-Dimethoxystrychnine | 145428-94-0

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马钱子生物碱
• 英文名称: 10,11-Dimethoxystrychnine
• 英文别名: (4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one;dihydrate
• CAS: 145428-94-0
• 化学式: C23H30N2O6
• 分子量: 430.5
• InChiKey: VWLBJWIPYIYRBM-FIMIILAWSA-N

物化性质

• 熔点：
  174 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.46
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  53.2
• 氢给体数：
  2
• 氢受体数：
  7

安全信息

• 海关编码：
  29399920

文献信息

• 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
  申请人：——

  公开号：US20030195356A1

  公开（公告）日：2003-10-16

  4-Aryl- 1 -(indanmethyl, dibydrobenzofuramethyl or dihydrobenzotbiophenemethyl) piperidine, -tetrabydropyridine or -piperazine compounds of general formula (I) 1 wherein one of X and Y is CH 2 , and the other one is CH 2 , O or S; Z is N, C, CH or COH; Ar is an optionally substituted aryl group; R 1 is hydrogen, alkyl, cycloalkyl, cycloakylalkyl, aryl, arylalkyl, acyl, thioacyl, alkylsulfonyl, trifloromethylsulfonyl, arylsulfonyl, a group R 9 VCO— where V is O or S and R 9 is alkyl or aryl, or a group R 10 R 11 NCO or R 10 R 11 NCS— wherein R 10 and R 11 are hydrogen, alkyl or aryl, or R 10 and R 11 are linked to form a ring R 2 is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; or R 1 and R 2 are linked to form a ring; R 3 —R 5 are hydrogen, halogen, alkyl, alkylcarbonyl, phenylcarbonyl, alkoxy, alkylthio, hydroxy, alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylaLkyl or nitro; R 6 and R 7 are bydrogen or alkyl or they are linked to constitute a 3-7-membered ring; R 8 is hydrogen or alkyl; have effects at central serotonergic receptors and are therefore useful in the treatment of certain psychic and neurologic disorders.

  通式（I）的4-芳基-1-(茚达甲基、二氢苯并呋喃甲基或二氢苯并二苯甲基)-哌啶、四氢吡啶或哌嗪化合物，其中X和Y中的一个是CH2，另一个是 、O或S；Z是N、C、CH或COH；Ar是可选取代的芳基基团；R1是氢、烷基、环烷基、环烷基烷基、芳基、芳基烷基、酰基、硫酰基、烷基磺酰基、三氟甲基磺酰基、芳基磺酰基、R9VCO—其中V为O或S且R9为烷基或芳基，或R10R11NCO或R10R11NCS—其中R10和R11为氢、烷基或芳基，或R10和R11连接形成环；R2是氢、烷基、环烷基或环烷基烷基；或R1和R2连接形成环；R3-R5是氢、卤素、烷基、烷基羰基、苯基羰基、烷氧基、烷基硫基、羟基、烷基磺酰基、氰基、三氟甲基、环烷基、环烷基烷基或硝基；R6和R7是氢或烷基，或它们连接构成3-7成员环；R8是氢或烷基；在中枢5-羟色胺受体上具有作用，因此在治疗某些精神和神经疾病方面有用。
• Spiro-3-hetero-azolones for treatment of diabetic complications
  申请人：PFIZER INC.

  公开号：EP0115133A1

  公开（公告）日：1984-08-08

  Compounds of the formula and their pharmaceutically acceptable salts, wherein: U is oxygen, sulfur or nitrogen substituted with hydrogen or alkyl having 1-4 carbon atoms; n is zero or one; W is carbonyl or hydroxymethylene; R is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen, chloro, bromo, iodo, alkyl having 1-4 carbon atoms, dimethyl or (CH2)mQ wherein m is 1 or 2 and Q is phenyl or halophenyl, with the proviso that when X is dimethyl, n is one; Y is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms; and Z is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms, with the proviso that if either Y or Z is nitro the other is hydrogen. The compounds are useful in the treatment of certain chronic complications arising from diabetes mellitus, such as diabetic cataracts, retinopathy and neuropathy.

  式中的化合物 及其药学上可接受的盐类，其中 U 是被氢或具有 1-4 个碳原子的烷基取代的氧、硫或氮； n 为 0 或 1 W 是羰基或羟基亚甲基； R 是氢或具有 1-4 个碳原子的烷基； X 是氢、氯、溴、碘、具有 1-4 个碳原子的烷基、二甲基或 (CH2)mQ，其中 m 是 1 或 2，Q 是苯基或卤代苯基，但当 X 是二甲基时，n 是 1； Y 是氢、卤素、硝基、三氟甲基、具有 1-4 个碳原子的烷氧基或具有 1-4 个碳原子的烷基；及 Z 是氢、卤素、硝基、三氟甲基、具有 1-4 个碳原子的烷氧基或具有 1-4 个碳原子的烷基，但如果 Y 或 Z 是硝基，则另一个是氢。 这些化合物可用于治疗糖尿病引起的某些慢性并发症，如糖尿病性白内障、视网膜病变和神经病变。
• Quinazolinone compounds and processes for the preparation thereof
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0204534A2

  公开（公告）日：1986-12-10

  There are described novel quinazolinone compounds of the formula: wherein R is hydrogen atom or a lower alkyl, R1 is a lower alkyl, a substituted or unsubstituted phenyl or an aralkyl, and R2, R3, R4 and R5 are the same or different and are each hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, a lower alkoxycarbonyl or a lower alkoxycarbonyl-lower alkenyl, ortwo adjacent groups of R2, R3, R4 and R5 when taken together form methylenedioxy and the other two are hydrogen atom, and salts thereof. The compounds are useful for the prophylaxis and treatment of various diabetic complications. There are also disclosed processes for the preparation of compound of formula I, and pharmaceutical compositions containing such compound as an active ingredient.

  描述了式中的新型喹唑啉酮化合物： 其中 R 是氢原子或低级烷基，R1 是低级烷基、取代或未取代的苯基或芳烷基，R2、R3、R4 和 R5 相同或不同，并且各自是氢原子、卤素原子、低级烷基、低级烷氧基、低级烷氧羰基或低级烷氧羰基-低级烯基，或者 R2、R3、R4 和 R5 的两个相邻基团在一起时形成亚甲基二氧基，另外两个是氢原子，以及它们的盐。这些化合物可用于预防和治疗各种糖尿病并发症。此外，还公开了制备式 I 化合物的工艺和含有此类化合物作为活性成分的药物组合物。
• Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0200391A2

  公开（公告）日：1986-12-10

  Substituted 2,3,4,9-tetrahydro-1H-carbazole-1- acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents. The derivatives are acids of formula I below or their salts. In formula (I) R1, R2, R3, R4, R5 and R6 are hydrogen or lower alkyl or R3 and R4 are joined together to form (CH2)m or R5 and R6 are joined together to form R8 and R10 are independently hydrogen, lower alkyl or halogen, R9 is hydrogen or lower alkyl, m is 2 to 3 and n is 2 to 4.

  本发明公开了取代的 2,3,4,9-四氢-1H-咔唑-1-乙酸衍生物及其制备和使用方法。 这些化合物是有用的镇痛剂和消炎剂。 这些衍生物是下式 I 的酸或其盐。 在式 (I) 中，R1、R2、R3、R4、R5 和 R6 是氢或低级烷基，或 R3 和 R4 连接在一起形成 (CH2)m 或 R5 和 R6 连接在一起形成 R8 和 R10 独立地是氢、低级烷基或卤素，R9 是氢或低级烷基，m 是 2 至 3，n 是 2 至 4。
• Optically active hydantoin derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0347733A1

  公开（公告）日：1989-12-27

  An optically active hydantoin compound, -6-halogen-­2,2-dimethyl-1′-(3-(4-hydroxypiperidino)-propyl)spiro­(chroman-4,4′-imidazolidine)-2′,5′-dione, having the formula: in which X is a halogen, and a pharmacologically acceptable acid addition salt thereof are novel and useful for the pharmacological use, such as an antiarrhythmia agent. X is preferably chlorine.

  一种具有光学活性的海因化合物-6-卤素-2,2-二甲基-1′-(3-(4-羟基哌啶基)-丙基)螺(色满-4,4′-咪唑烷)-2′,5′-二酮，其式为 其中X为卤素，其药理学上可接受的酸加成盐是新颖的，可用于药理学用途，如抗心律失常剂。X最好是氯。