diethyl 2-(p-tolyl)maleate | 251570-98-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: diethyl 2-(p-tolyl)maleate
• 英文别名: Diethyl 2-(4-methylphenyl)but-2-enedioate
• CAS: 251570-98-6
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: BNYUNSXLQDFUCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙醇 、 一氧化碳 、 4-甲苯基乙炔 在 palladium 10% on activated carbon 、 氧气 、 四丁基碘化铵 作用下， 以 乙醇 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 8.0h， 以90%的产率得到diethyl 2-(p-tolyl)maleate
  参考文献：
  名称：

  Synthesis of α,β-Alkynyl Esters and Unsymmetrical Maleate Esters Catalyzed by Pd/C; An Efficient Phosphine-Free Catalytic System for Oxidative Alkoxycarbonylation of Terminal Alkynes

  摘要：

  Pd/C-catalyzed oxidative alkoxycarbonylation of terminal alkynes using alcohols in the presence of tetrabutylammonium iodide under CO/O-2 (5:1 atm) has been investigated. The desired alpha,beta-alkynyl esters and unsymmetrical maleate esters are formed in good to excellent yields under different reaction conditions. The present protocol eliminates the use of phosphine ligands and has straightforward catalyst recovery. The catalyst was recycled up to six times without significant loss of catalytic activity.

  DOI：

  10.1055/s-0032-1316896

文献信息

• NOVEL VINYLBENZENE DERIVATIVES
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1094055A1

  公开（公告）日：2001-04-25

  The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, wherein R1 is H, lower alkyl or phenyl, and the phenyl can be substituted by lower alkyl, hydroxy, lower alkoxy, halogen, nitro or phenyl; R2 and R3, being the same or different, are H, halogen or lower alkyl; R4 and R5, being the same or different, are H, lower alkyl or carboxyl or ester thereof; and R6 is carboxyl or phosphono or ester thereof.

  本发明提供了由下通式[I]代表的化合物及其盐类，它们可用作青光眼的治疗剂、 其中 R1 是 H、低级烷基或苯基，苯基可被低级烷基、羟基、低级烷氧基、卤素、硝基或苯基取代；R2 和 R3 相同或不同，是 H、卤素或低级烷基；R4 和 R5 相同或不同，是 H、低级烷基或羧基或其酯；R6 是羧基或膦酰基或其酯。
• US6329547B1
  申请人：——

  公开号：US6329547B1

  公开（公告）日：2001-12-11
• Synthesis of α,β-Alkynyl Esters and Unsymmetrical Maleate Esters Catalyzed by Pd/C; An Efficient Phosphine-Free Catalytic System for Oxidative Alkoxycarbonylation of Terminal Alkynes
  作者：Bhalchandra Bhanage、Sandip Gadge

  DOI：10.1055/s-0032-1316896

  日期：——

  Pd/C-catalyzed oxidative alkoxycarbonylation of terminal alkynes using alcohols in the presence of tetrabutylammonium iodide under CO/O-2 (5:1 atm) has been investigated. The desired alpha,beta-alkynyl esters and unsymmetrical maleate esters are formed in good to excellent yields under different reaction conditions. The present protocol eliminates the use of phosphine ligands and has straightforward catalyst recovery. The catalyst was recycled up to six times without significant loss of catalytic activity.