(1,4-dimethyl-2,5,11-trioxo-6H-pyrido[2,3-h]carbazol-7-yl)methyl acetate | 876515-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1,4-dimethyl-2,5,11-trioxo-6H-pyrido[2,3-h]carbazol-7-yl)methyl acetate
• CAS: 876515-29-6
• 化学式: C₂₀H₁₆N₂O₅
• 分子量: 364.357
• InChiKey: CQUJEFINZJSIOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-(2-acetoxymethylphenylamino)-1,4-dimethylquinoline-2(1H),5,8-trione 在 palladium diacetate 作用下， 以 溶剂黄146 为溶剂， 反应 16.0h， 以89%的产率得到(1,4-dimethyl-2,5,11-trioxo-6H-pyrido[2,3-h]carbazol-7-yl)methyl acetate
  参考文献：
  名称：

  Synthesis of Pyrido[3,2-b]carbazolequinones Involving N-Arylation of 5,8-Dimethoxy-6-nitroquinolines by Aryl Grignard Reagents and a New One-Pot, Palladium-Promoted Oxidative Coupling-Oxidative Demethylation Sequence

  摘要：

  The reaction between a 5,8-dimethyxy-6-nitrocarbostyril derivative and arylmagnesium bromides gave 6-arylaminocarbostyrils as the major products. Their subsequent treatment with palladium acetate in refluxing acetic acid gave linear pyrido[3,2-b]carbazolequinones in one step, involving the unprecedented oxidative demethylation of 1,4-dimethoxybenzene systems to the corresponding quinones by palladium acetate. A palladium-calalyzed oxidative functionalization of an unactivated C-H bond was also observed.

  DOI：

  10.1055/s-2008-1072751