methyl 2-formyl-3-(4-methoxyphenyl)prop-2-enoate | 1412709-29-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl 2-formyl-3-(4-methoxyphenyl)prop-2-enoate
• CAS: 1412709-29-5
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: RVRZANHDEIDLQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-formyl-3-(4-methoxyphenyl)prop-2-enoate 、 3,4,6-tri-O-benzyl-2-ethenyl-D-glucal 以 甲苯 为溶剂， 反应 15.0h， 以65%的产率得到(2R,3S,4R,7S,8S,8aR)-methyl 3,4-bis(benzyloxy)-2-(benzyloxymethyl)-8-formyl-7-(4-methoxyphenyl)-3,4,6,7,8,8a-hexahydro-2H-chromene-8-carboxylate
  参考文献：
  名称：

  Parasuraman, Kadigachalam; Dubbu, Sateesh; Chennaiah, Ande, Journal of the Indian Chemical Society, 2020, vol. 97, # 2, p. 187 - 196

  摘要：

  DOI：

文献信息

• Stereoselective Cascade Double-Annulations Provide Diversely Ring-Fused Tetracyclic Benzopyrones
  作者：Baburaj Baskar、Kathrin Wittstein、Muthukumar G. Sankar、Vivek Khedkar、Markus Schürmann、Kamal Kumar

  DOI：10.1021/ol3028412

  日期：2012.12.7

  A cascade double-annulation strategy employing diverse pairs of zwitterions with 3-formylchromones is presented that provides stereoselective access to complex tetracyclic benzopyrones. Different zwitterions incorporated different rings that include aza-, oxa-, and carbocycles fused to a common benzopyrone scaffold and in the process created three contiguous chiral centers including an all-carbon-quaternary center with high efficiency and excellent stereoselectivity.
• Parasuraman, Kadigachalam; Dubbu, Sateesh; Chennaiah, Ande, Journal of the Indian Chemical Society, 2020, vol. 97, # 2, p. 187 - 196
  作者：Parasuraman, Kadigachalam、Dubbu, Sateesh、Chennaiah, Ande、Ibrahim Sheriff、Vankar, Yashwant D.

  DOI：——

  日期：——