2-hydroxy-4-(3-((E)-3-(4-chlorophenyl)acrylamido)phenyl)-4-oxobut-2-enoic acid | 1153623-29-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-hydroxy-4-(3-((E)-3-(4-chlorophenyl)acrylamido)phenyl)-4-oxobut-2-enoic acid
• CAS: 1153623-29-0
• 化学式: C₁₉H₁₄ClNO₅
• 分子量: 371.777
• InChiKey: TVGDGROMNKHJPS-YGNMSSQISA-N

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 、 水 、 盐酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 2-hydroxy-4-(3-((E)-3-(4-chlorophenyl)acrylamido)phenyl)-4-oxobut-2-enoic acid
  参考文献：
  名称：

  Amide-containing diketoacids as HIV-1 integrase inhibitors: Synthesis, structure–activity relationship analysis, and biological activity

  摘要：

  HIV-1 integrase, which catalyzes the integration of the viral genome into the cellular chromosome, is an essential enzyme for retroviral replication, and represents an attractive and validated target in the development of therapeutics against AIDS. In this paper, 17 amide-containing novel diketoacids were designed and synthesized, and their ability to inhibit HIV-1 integrase was tested. The structure-activity relationships were also analyzed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.01.077