| 1144522-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1144522-47-3
• 化学式: C₁₅H₈ClFN₂O₃
• 分子量: 318.692
• InChiKey: YRINMNHRAXBDTB-UHFFFAOYSA-N

物化性质

• 沸点：
  431.2±45.0 °C(predicted)
• 密度：
  1.479±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 platinum on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors

  摘要：

  Aniline 'headgroups' were synthesized and incorporated into an alkynyl thienopyrimidine series of EGFR and ErbB-2 inhibitors. Potent inhibition of enzyme activity and cellular proliferation was observed. In certain instances, protein binding was reduced and oral exposure was found to be somewhat improved relative to compounds containing the reference aniline. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.080