| 1145724-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1145724-91-9
• 化学式: C₁₁H₅ClF₃IN₂O
• 分子量: 400.526
• InChiKey: ILZXIJDAVPFPPL-UHFFFAOYSA-N

物化性质

• 沸点：
  447.2±45.0 °C(predicted)
• 密度：
  1.972±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  在 ammonium hydroxide 作用下， 生成
  参考文献：
  名称：

  Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

  摘要：

  Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD.

  DOI：

  10.1016/j.bmcl.2009.01.045