4'-N,N-dimethylamino-2-trans-styryl-(6-chloroquinoline) | 53653-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4'-N,N-dimethylamino-2-trans-styryl-(6-chloroquinoline)
• 英文别名: 4-[trans-2-(6-chloro-[2]quinolyl)-vinyl]-N,N-dimethyl-aniline；4-[trans-2-(6-Chlor-[2]chinolyl)-vinyl]-N,N-dimethyl-anilin；4-[(E)-2-(6-chloroquinolin-2-yl)ethenyl]-N,N-dimethylaniline
• CAS: 53653-98-8
• 化学式: C₁₉H₁₇ClN₂
• 分子量: 308.81
• InChiKey: BKFOZNJCLPYKNS-FPYGCLRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-氯-2-甲基喹啉 、 对二甲氨基苯甲醛 在 盐酸 作用下， 生成 4'-N,N-dimethylamino-2-trans-styryl-(6-chloroquinoline)
  参考文献：
  名称：

  Takahashi; Satake, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 1183,1186

  摘要：

  DOI：

文献信息

• Photophysics and applications in biosensor for 4′-N,N-dimethylamino-2-trans-styryl-(6-chloroquinoline)
  作者：Shun-Li Wang、Ju-Mei Lin

  DOI：10.1016/j.cplett.2007.06.122

  日期：2007.8

  A push-pull compound with intramolecular charge transfer (ICT) characteristic, 6-Cl-2-StQ-NMe2, was synthesized in this work. The emission maxima of 6-Cl-2-StQ-NMe2 correlates excellently with the static polarity of the environment. In an aqueous solution, 6-Cl-2-StQ-NMe2 was observed to form an 'H type' aggregate in the ground state, but deaggregation occurred in the excited state. We find that 6-Cl-2-StQ-NMe2 can be used as a biosensor. Quantitative analysis showed that a linear relationship exists when bovine serum albumin (BSA) concentration is between 40 mu g/ml and 5000 mu g/ml. While monitoring the conformational change of BSA, the denaturation reaction was observed when the temperature exceeded 60 degrees C. (c) 2007 Elsevier B.V. All rights reserved.