Flavinadeninedinucleotidedisodium(FADdisodium) | 84366-81-4

• 物质功能分类: 生物化工 - 核苷类药物 - 核苷酸及其类似物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: Flavinadeninedinucleotidedisodium(FADdisodium)
• CAS: 84366-81-4
• 化学式: C27H33N9NaO15P2
• 分子量: 808.5
• InChiKey: NQOZVHXDRLWYCQ-WQLILBPHSA-N

物化性质

• 熔点：
  >203°C (dec.)
• 溶解度：
  可溶于甲醇（轻微加热）、水（轻微）

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  29339900
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

Flavin adenine dinucleotide (FAD) disodium salt 是一种氧化还原辅因子，蛋白质的辅基，在代谢过程中参与了几个重要的酶反应。

靶点

Human Endogenous Metabolite

体外研究

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 ^-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.

体内研究

With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.

用途 

主要用于丁苯橡胶及其他高分子乳液催化聚合配制乳化剂

用途 

flavoprotins 的氧化还原辅酶

用途 

用作黄素蛋白的氧化还原辅因子（电子载体），这些黄素蛋白包括琥珀酸脱氢酶（复合物）、α-酮戊二酸脱氢酶、凋亡诱导因子2（AIF-M2，AMID）、叶酸/FAD依赖性tRNA甲基转移酶和N-羟基化黄素蛋白单加氧酶。 FAD是丙酮酸脱氢酶复合物的组分。