Bioactivatable derivatives of 8-substituted cAMP-analogues
摘要:
Four 8-substituted derivatives of cAMP were converted into their membrane-permeant acetoxymethyl esters (AM-esters). The activity of these bioactivatable compounds to induce chloride secretion of T-84 cells was up to 100-fold increased compared to the non-modified cAMP derivatives. (C) 1997 Elsevier Science Ltd.