(2R,3R,4S,5R,6R)-5-氟-2-(羟基甲基)-6-甲氧基四氢吡喃-3,4-二醇 | 79698-13-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2R,3R,4S,5R,6R)-5-氟-2-(羟基甲基)-6-甲氧基四氢吡喃-3,4-二醇
• 英文名称: methyl 2-deoxy-2-fluoro-β-D-galactopyranoside
• 英文别名: Methyl 2-deoxy-2-fluoro-D-galactopyranoside；(2R,3R,4S,5R,6R)-5-fluoro-2-(hydroxymethyl)-6-methoxyoxane-3,4-diol
• CAS: 79698-13-8
• 化学式: C₇H₁₃FO₅
• 分子量: 196.176
• InChiKey: CRIUOMMBWCCBCQ-XUUWZHRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 2-deoxy-2-fluoro-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside 在 溶剂黄146 作用下， 生成 (2R,3R,4S,5R,6R)-5-氟-2-(羟基甲基)-6-甲氧基四氢吡喃-3,4-二醇
  参考文献：
  名称：

  Haradahira, Terushi; Maeda, Minoru; Yano, Yuji, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 8, p. 3317 - 3319

  摘要：

  DOI：

文献信息

• Preparation of two methyl deoxyfluoro-β-d-galactopyranosides, and their interaction with galactan-specific immunoglobulin A 1539 (fab′)
  作者：Yitzhak Ittah、Cornelis P.J. Glaudemans

  DOI：10.1016/s0008-6215(00)85575-5

  日期：1981.9

  Methyl 2-deoxy-2-fluoro-beta-D-glactopyranoside (2) and methyl 4-deoxy-4-fluoro-beta-D-glactopyranoside (7) have been prepared, and the possibility of their binding to (1 leads to 6)-beta-D-galactopyranan-specific immunoglobulin A J539 (Fab') has been investigated. Compound 2 does not show binding, whereas 7 does. It appears that the 2-hydroxyl group of methyl beta-D-galactopyranoside may take part in hydrogen bonding to the protein.