(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-12-(3-aminopropoxy)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-13-hydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione | 911673-64-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-12-(3-aminopropoxy)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-13-hydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
• CAS: 911673-64-8
• 化学式: C₄₁H₇₆N₂O₁₃
• 分子量: 805.06
• InChiKey: RPLTXAWWHINBCT-IWYZJZKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  56
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  198
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  11-cyanoethohy clarithromycin 在 platinum(IV) oxide 氢气 、 溶剂黄146 作用下， 反应 5.0h， 生成 (3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-12-(3-aminopropoxy)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-13-hydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
  参考文献：
  名称：

  WO2006/106440

  摘要：

  公开号：

文献信息

• Macrolide Compounds Containing Biotin and Photo-Affinity Group for Macrolide Target Identification
  申请人：Culic Ognjen

  公开号：US20080241959A1

  公开（公告）日：2008-10-02

  The present invention relates to new macrolide compounds represented by the general structure I, wherein M is a macrolide, P is a photo-affinity group bearing subunit containing biotin, and L is a linking molecule, and to their pharmaceutically acceptable salts and solvates, to processes and intermediates for their preparation and to the use of these compounds for the macrolide target identification.
• US7989600B2
  申请人：——

  公开号：US7989600B2

  公开（公告）日：2011-08-02
• WO2006/106440
  申请人：——

  公开号：——

  公开（公告）日：——