盐酸鲁米诺 | 74165-64-3

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 盐酸鲁米诺
• 英文名称: 5-Amino-2,3-dihydrophthalazine-1,4-dione hydrochloride
• 英文别名: 5-amino-2,3-dihydrophthalazine-1,4-dione;hydrochloride
• CAS: 74165-64-3
• 化学式: C8H8ClN3O2
• 分子量: 213.62
• InChiKey: SCHUENIUEDOXQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.22
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.2
• 氢给体数：
  4
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi

文献信息

• Combination artemisinin and chemiluminescent photodynamic therapy and uses therefor
  申请人：Washington University

  公开号：US10925963B2

  公开（公告）日：2021-02-23

  Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ALA), luminol and artemisinin (ART). ART and ALA administered in combination with luminol can kill malaria parasites without host toxicity. In some aspects, the methods further include administration of a luminol enhancer such as 4-iodophenol. The disclosed methods can also be used to remove potential malaria pathogens from the blood supply.

  本文公开了基于光动力疗法治疗癌症和疟疾等疾病的方法。这些方法包括施用 5-氨基乙酰丙酸（ALA）、鲁米诺和青蒿素（ART）。ART 和 ALA 与鲁米诺结合使用可杀死疟原虫，而不会对宿主产生毒性。在某些方面，这些方法还包括施用发光酚增强剂，如 4-碘苯酚。所公开的方法还可用于清除血液供应中潜在的疟疾病原体。
• Method for correcting immune system of live body
  申请人：——

  公开号：US20030195183A1

  公开（公告）日：2003-10-16

  The present invention relates to medicine and veterinary, namely, to immunology, and to methods aimed at correcting the immune system of a living organism. The essence of the invention is in the immunocorrection of the organism using pharmacologically appropriate amino derivatives of 2,3-dihydrophthalazine-1,4˜dione in their effective doses ranging from 0.2 &mgr;g to 1,000 mg.

  本发明涉及医学和兽医学，即免疫学，以及旨在纠正生物体免疫系统的方法。本发明的精髓在于使用药理上适当的 2,3-二氢酞嗪-1,4˜二酮的氨基衍生物对生物体进行免疫矫正，其有效剂量从 0.2 毫克到 1,000 毫克不等。
• AMINO DERIVATIVES OF 2,3-DIHYDROPHTALAZINE-1,4-DIONE AS IMMUNOCORRECTING AGENTS
  申请人：Medinkor ZMM AG

  公开号：EP1315497A2

  公开（公告）日：2003-06-04
• COMBINATION ARTEMISININ AND CHEMILUMINESCENT PHOTODYNAMIC THERAPY AND USES THEREFOR
  申请人：Washington University

  公开号：US20160367674A1

  公开（公告）日：2016-12-22

  Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ALA), luminol and artemisinin (ART). ART and ALA administered in combination with luminol can kill malaria parasites without host toxicity. In some aspects, the methods further include administration of a luminol enhancer such as 4-iodophenol. The disclosed methods can also be used to remove potential malaria pathogens from the blood supply.
• [EN] A METHOD FOR CORRECTING THE IMMUNE SYSTEM OF LIVE BODY<br/>[FR] TECHNIQUE DE CORRECTION DU SYSTEME IMMUNITAIRE DE CORPS VIVANT
  申请人：MEDINKOR ZMM AG

  公开号：WO2002009681A2

  公开（公告）日：2002-02-07

  This invention belongs to a field of medicine and veterinary, namely, immunology, and relates to methods aimed at correcting the immune system of live body. The essence of the invention is in the immunocorrection of the body with the use of pharmacologically appropriate amino derivatives of 2,3-dihydrophthalazine-1,4-dione in their effective in their effective doses ranging from 0.2 μg to 1,000mg.