1-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]ethan-1-one | 401892-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]ethan-1-one
• 英文别名: 4-acetylphenyltetetrafluoro-λ⁶-sulfanyl chloride；1-[4-(pentafluoro-sulfanyl)phenyl]ethanone；4'-(Pentafluorosulfur)acetophenone；1-[4-(pentafluoro-λ6-sulfanyl)phenyl]ethanone
• CAS: 401892-83-9
• 化学式: C₈H₇F₅OS
• 分子量: 246.201
• InChiKey: BKEQOPIQGDSWEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  18.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]ethan-1-one 在 phenyltrimethylammonium tribromide 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2-bromo-1-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]ethan-1-one
  参考文献：
  名称：

  [EN] (4-PHENYLIMIDAZOL-2-YL) ETHYLAMINE DERIVATIVES USEFUL AS SODIUM CHANNEL MODULATORS
  [FR] COMPOSÉS CHIMIQUES

  摘要：

  公开号：

  WO2013061205A8
• 作为产物：
  描述：

  五氟化(4-酰氯苯基)硫 在 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 1-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]ethan-1-one
  参考文献：
  名称：

  [EN] (4-PHENYLIMIDAZOL-2-YL) ETHYLAMINE DERIVATIVES USEFUL AS SODIUM CHANNEL MODULATORS
  [FR] COMPOSÉS CHIMIQUES

  摘要：

  公开号：

  WO2013061205A8

文献信息

• Validation of Arylphosphorothiolates as Convergent Substrates for Ar-SF4Cl and Ar-SF5 Synthesis
  作者：Josep Cornella、Lin Wang、Shengyang Ni

  DOI：10.1055/s-0040-1706039

  日期：2021.11

  the oxidative fluorination of aryl phosphorothiolates to access Ar-SF4Cl compounds. These compounds serve as precursors for the highly coveted Ar-SF5 compounds. The use of phosphorothiolates as starting materials permits access to Ar-SF4Cl from a wide variety of available starting materials, namely boronic acids, diazonium salts, aryl iodides, thiophenols, or simple arenes. The protocol has been demonstrated

  在本手稿中，我们描述了芳基硫代磷酸酯的氧化氟化反应，以获取Ar-SF 4 Cl化合物。这些化合物用作高度渴望的Ar-SF 5化合物的前体。使用硫代磷酸酯作为起始原料可以从多种可用的起始原料，即硼酸，重氮盐，芳基碘化物，苯硫酚或简单的芳烃中获得Ar-SF 4 Cl。该协议已针对> 10个示例进行了证明，并显示出对各种功能基团的良好耐受性。最后，我们证明了AgBF 4可以用作氟化剂，并提供良好的Ar-SF 5收率。
• PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AIDS, AND MEDICAMENTS COMPRISING THEM
  申请人：KLEEMANN Heinz-Werner

  公开号：US20080200553A1

  公开（公告）日：2008-08-21

  Pentafluorosulfanylbenzoylguanidines of the formula I and II in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

  公式I和II中R1到R4的含义如权利要求中所述的五氟硫基苯甲酰基胍类化合物，适用于具有心脏保护成分的抗心律失常药物，用于预防心肌梗死和治疗心肌梗死以及治疗心绞痛。它们还可以预防性地抑制与缺血性损伤发展相关的病理生理过程，特别是在缺血性心脏心律失常的触发中。
• (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
  申请人：Pfizer Limited

  公开号：US09079878B2

  公开（公告）日：2015-07-14

  The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole NaV1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. NaV1.8 modulators are useful in the treatment of a wide range of disorders, particularly pain.

  本发明涉及咪唑衍生物，其在医学上的应用，包含它们的组成物，制备过程以及用于这种过程的中间体。更具体地，本发明涉及一种新的咪唑NaV1.8调节剂，其化学式为(I)，或其药学上可接受的盐，其中R1，R2，R3，R4和R5如描述中所定义。NaV1.8调节剂在治疗广泛的疾病中特别是疼痛方面有用。
• (4-Phenylimidazol-2-yl) Ethylamine Derivatives Useful As Sodium Channel Modulators
  申请人：Pfizer Limited

  公开号：US20140296313A1

  公开（公告）日：2014-10-02

  The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole Na V 1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description. Na V 1.8 modulators useful in the treatment of a wide range of disorders, particularly pain.

  本发明涉及咪唑衍生物，其在医学上的应用，包含它们的组合物，制备它们的方法以及用于这些方法的中间体。更具体地，本发明涉及一种新的咪唑NaV1.8调节剂，其化学式为(I)或其药学上可接受的盐，其中R1、R2、R3、R4和R5如描述中所定义。NaV1.8调节剂在治疗各种疾病，特别是疼痛方面具有用途。
• GAMMA SECRETASE MODULATORS
  申请人：Zhu Zhaoning

  公开号：US20100298381A1

  公开（公告）日：2010-11-25

  In its many embodiments, the present invention provides a novel class of 5-membered, nitrogen-containing heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的5-成员、含氮杂环化合物作为γ-分泌酶调节剂，制备这种化合物的方法，含有一种或多种这种化合物的制药组合物，制备包含一种或多种这种化合物的制药制剂的方法，以及使用这种化合物或制药组合物治疗、预防、抑制或改善与中枢神经系统相关的一种或多种疾病的方法。