4-methoxy-2-methylisobutyrophenone | 54696-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-2-methylisobutyrophenone
• 英文别名: 2,2'-Dimethyl-4'-methoxypropiophenone；1-(4-methoxy-2-methylphenyl)-2-methylpropan-1-one
• CAS: 54696-07-0
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: VGJCPXBTYHBKAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-2-methylisobutyrophenone 在 phenyltrimethylammonium tribromide 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 α-bromo-4-methoxy-2-methylisobutyrophenone
  参考文献：
  名称：

  [EN] FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE
  [FR] COMPOSITION FONGICIDE CONTENANT UN DÉRIVÉ D'AMIDE D'ACIDE

  摘要：

  传统的许多杀真菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，控制植物病害的效果往往不足，因此需要一种能够克服这些问题的杀真菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐的杀真菌组合物作为活性成分：其中A是苯基，可能被取代，苄基，可能被取代，萘基，可能被取代，杂环环，可能被取代，融合的杂环环，可能被取代，或类似物；B是可能被取代的杂环环，融合的可能被取代的杂环环，或可能被取代的萘基；R1和R2各自独立的，是烷基，或类似物；R3是氢，或类似物；W1和W2各自独立的，是氧或硫。

  公开号：

  WO2006016708A1
• 作为产物：
  描述：

  1-(4-羟基-2-甲基苯基)-2-甲基丙烷-1-酮 、 硫酸二甲酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-methoxy-2-methylisobutyrophenone
  参考文献：
  名称：

  [EN] FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE
  [FR] COMPOSITION FONGICIDE CONTENANT UN DÉRIVÉ D'AMIDE D'ACIDE

  摘要：

  传统的许多杀真菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，控制植物病害的效果往往不足，因此需要一种能够克服这些问题的杀真菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐的杀真菌组合物作为活性成分：其中A是苯基，可能被取代，苄基，可能被取代，萘基，可能被取代，杂环环，可能被取代，融合的杂环环，可能被取代，或类似物；B是可能被取代的杂环环，融合的可能被取代的杂环环，或可能被取代的萘基；R1和R2各自独立的，是烷基，或类似物；R3是氢，或类似物；W1和W2各自独立的，是氧或硫。

  公开号：

  WO2006016708A1

文献信息

• Fungicidal Composition Containing Acid Amide Derivative
  申请人：Nakamura Yuji

  公开号：US20080318779A1

  公开（公告）日：2008-12-25

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R 1 and R 2 which are independent of each other, is alkyl, or the like; R 3 is hydrogen, or the like; each of W 1 and W 2 which are independent of each other, is oxygen or sulfur.

  传统的许多杀菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果倾向于不足，或者根据应用场所，对植物疾病的控制效果倾向于不足，因此需要一种克服这些问题的杀菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐作为活性成分的杀菌组合物：其中，A是苯基，可以是取代的苯基，苄基，可以是取代的苄基，萘基，可以是取代的萘基，杂环环，可以是取代的杂环环，融合的杂环环，可以是取代的融合的杂环环或类似物；B是杂环环，可以是取代的融合的杂环环或取代的萘基；R1和R2各自独立地是烷基或类似物；R3是氢或类似物；W1和W2各自独立地是氧或硫。
• FUNGICIDAL COMPOSITION CONTAINING CARBOXYLIC ACID AMIDE DERIVATIVE
  申请人：Nakamura Yuji

  公开号：US20100222337A1

  公开（公告）日：2010-09-02

  Conventional fungicidal compositions have had practical problems such that either a preventive effect or a curative effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing a carboxylic acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzodioxolanyl which may be substituted, or benzodioxanyl which may be substituted; B is 2- or 3-pyridyl which may be substituted; each of R 1 and R 2 is alkyl, or R 1 and R 2 may together form a 3- to 6-membered saturated carbon ring, provided that when B is 3-pyridyl which may be substituted, A is phenyl substituted by at least two substituents.

  传统的杀菌剂组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，对植物疾病的控制效果往往不足，因此需要一种克服这些问题的杀菌剂组合物。本发明提供了一种含有式(I)的羧酸酰胺衍生物或其盐作为活性成分的杀菌剂组合物：其中A是苯基，可以是取代的苯基，苯并二氧杂环基，可以是取代的苯并二氧杂环基，或苯并二氧杂环基，可以是取代的苯并二氧杂环基；B是2-或3-吡啶基，可以是取代的；R1和R2中的每一个都是烷基，或者R1和R2可以共同形成3-至6-成员的饱和碳环，但是当B是可以被取代的3-吡啶基时，A是至少被两个取代基取代的苯基。
• FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE
  申请人：Nakamura Yuji

  公开号：US20100261675A1

  公开（公告）日：2010-10-14

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R 1 and R 2 which are independent of each other, is alkyl, or the like; R 3 is hydrogen, or the like; each of W 1 and W 2 which are independent of each other, is oxygen or sulfur.

  传统的多种杀菌剂组合存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，对植物疾病的控制效果往往不足，因此需要一种能够克服这些问题的杀菌剂组合。本发明提供了一种杀菌剂组合，其包含式（I）的酸酰胺衍生物或其盐作为活性成分：其中A是苯基，可以是取代的苯基，苄基，可以是取代的苄基，萘基，可以是取代的萘基，杂环环，可以是取代的杂环环，融合的杂环环，可以是取代的融合的杂环环等；B是杂环环，可以是取代的融合的杂环环或萘基，可以是取代的萘基；R1和R2各自独立地是烷基或类似物；R3是氢或类似物；W1和W2各自独立地是氧或硫。
• Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles
  作者：Jie Gao、Xian-Chen He、Yan-Ling Liu、Ke-Rong Li、Jian-Ping Guan、Hong-Bin Chen、Hao-Yue Xiang、Kai Chen、Hua Yang

  DOI：10.1021/acs.orglett.3c03458

  日期：2023.12.15

  Herein, a visible-light-induced nickel-catalyzed cross-coupling of aryl bromide with nitrile has been reported. By utilization of readily available nitriles as carbonyl precursors, a range of structurally diverse aryl ketones were facilely constructed. The synthetic simplicity, mild reaction conditions, and acidic functional group tolerance would broaden the synthetic utilities of this developed protocol

  在此，报道了可见光诱导的镍催化芳基溴与腈的交叉偶联。通过利用容易获得的腈作为羰基前体，可以轻松构建一系列结构多样的芳基酮。合成简单性、温和的反应条件和酸性官能团耐受性将拓宽该开发方案的合成效用，作为格氏/有机锂方案的便捷替代方案。
• FUNGICIDAL COMPOSITION CONTAINING AN ACID AMIDE DERIVATIVE
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP1776011B1

  公开（公告）日：2012-03-21