2-(2-methylphenyl)iminomethylquinoline | 24641-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2-methylphenyl)iminomethylquinoline
• 英文别名: 2-methyl-N-quinolin-2-ylmethylene-aniline；N-(2-methylphenyl)-1-quinolin-2-ylmethanimine
• CAS: 24641-00-7
• 化学式: C₁₇H₁₄N₂
• 分子量: 246.312
• InChiKey: ZEBYXANYEMJHBO-UHFFFAOYSA-N

物化性质

• 熔点：
  70-71 °C(Solv: heptane (142-82-5))
• 沸点：
  420.3±20.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichloro(cycloocta-1,5-diene)palladium (II) 、 2-(2-methylphenyl)iminomethylquinoline 以 二氯甲烷 为溶剂， 反应 4.0h， 以89%的产率得到dichloro-[2-(2-methylphenyl)iminomethylquinoline]palladium (II)
  参考文献：
  名称：

  Imino-quinolyl palladium(II) and platinum(II) complexes: Synthesis, characterization, molecular structures and cytotoxic effect

  摘要：

  Imino-quinolyl ligands L1-L5 were synthesized by condensation reaction sand obtained in good yields. Reactions of the ligands with either PdCl2(cod) or K-2[PtCl4] gave the corresponding palladium(II) and platinum(II) complexes 1-10 also in good yields. All the compounds were characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy. X-ray crystallography was used to confirm the structures of these compounds. Molecular structures of 3 and 5 showed that the ligands coordinate to the metal center through the two nitrogen atoms, generating a distorted square planar geometry around the palladium atom. The new complexes exhibited remarkable cytotoxic activities against MCF-7 and HT-29 cancer cell lines. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.02.029
• 作为产物：
  描述：

  喹啉-2-甲醛 、 邻甲苯胺 以 二氯甲烷 为溶剂， 以92%的产率得到2-(2-methylphenyl)iminomethylquinoline
  参考文献：
  名称：

  Imino-quinolyl palladium(II) and platinum(II) complexes: Synthesis, characterization, molecular structures and cytotoxic effect

  摘要：

  Imino-quinolyl ligands L1-L5 were synthesized by condensation reaction sand obtained in good yields. Reactions of the ligands with either PdCl2(cod) or K-2[PtCl4] gave the corresponding palladium(II) and platinum(II) complexes 1-10 also in good yields. All the compounds were characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy. X-ray crystallography was used to confirm the structures of these compounds. Molecular structures of 3 and 5 showed that the ligands coordinate to the metal center through the two nitrogen atoms, generating a distorted square planar geometry around the palladium atom. The new complexes exhibited remarkable cytotoxic activities against MCF-7 and HT-29 cancer cell lines. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.02.029

文献信息

• Synthesis, spectroscopic study, X-ray diffraction, and comparative antimicrobial study of Schiff bases based on o-toluidine and their Co(II) complexes
  作者：Shobhana Sharma、Seema、Poonam Yadav、Suman Kumari、Mamta Ranka

  DOI：10.1016/j.jics.2023.100997

  日期：2023.6