| 1147012-64-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1147012-64-3
• 化学式: C₂₀H₃₂O₅Si
• 分子量: 380.557
• InChiKey: WHRWWRIURIQBRX-HFKIYIHZSA-N

物化性质

• 沸点：
  463.6±45.0 °C(predicted)
• 密度：
  1.11±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 咪唑 、 碘 、 三苯基膦 、 potassium tert-butylate 作用下， 生成 [(4aR,7R,8aS)-6-methylidene-2-phenyl-4a,7,8,8a-tetrahydro-4H-pyrano[3,2-d][1,3]dioxin-7-yl]oxy-triethylsilane
  参考文献：
  名称：

  Synthesis of 2-Methylenetetrahydropyran-3-ol Derivative, a Key Segment for Convergent Synthesis of Polycyclic Ethers Based on Suzuki-Miyaura Coupling

  摘要：

  2-Methylenetetrahydropyran-3-ol derivative, a key segment for convergent synthesis of polycyclic ethers based on Suzuki-Miyaura coupling, was efficiently synthesized by two methods; (1) via SmI2-induced reductive cyclization of beta-alkoxyvinyl sulfone with aldehyde followed by elimination of the sulforyl group, and (2) via SmI2-induced cyclization of beta-alkoxyvinyl sulfoxide with aldehyde followed by dehydration of the 2-hydroxymethyl group.

  DOI：

  10.3987/com-08-s(f)100
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 生成
  参考文献：
  名称：

  Synthesis of 2-Methylenetetrahydropyran-3-ol Derivative, a Key Segment for Convergent Synthesis of Polycyclic Ethers Based on Suzuki-Miyaura Coupling

  摘要：

  2-Methylenetetrahydropyran-3-ol derivative, a key segment for convergent synthesis of polycyclic ethers based on Suzuki-Miyaura coupling, was efficiently synthesized by two methods; (1) via SmI2-induced reductive cyclization of beta-alkoxyvinyl sulfone with aldehyde followed by elimination of the sulforyl group, and (2) via SmI2-induced cyclization of beta-alkoxyvinyl sulfoxide with aldehyde followed by dehydration of the 2-hydroxymethyl group.

  DOI：

  10.3987/com-08-s(f)100