3-羟基癸二酸 | 73141-46-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 3-羟基癸二酸
• 英文名称: 3-hydroxysebacic acid
• 英文别名: 3-Hydroxydecanedioic acid
• CAS: 73141-46-5；68812-93-1
• 化学式: C₁₀H₁₈O₅
• 分子量: 218.25
• InChiKey: OQYZCCKCJQWHIE-UHFFFAOYSA-N

物化性质

• LogP：
  0.245 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-环氧-9-癸烯 在 ruthenium trichloride 、 lithium hydroxide 、 sodium periodate 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 乙酸乙酯 、 乙腈 为溶剂， 反应 28.5h， 生成 3-羟基癸二酸
  参考文献：
  名称：

  一种方便的合成羟基二酸的通用方法

  摘要：

  带有末端双键的烯烃醛和环氧化物与格氏试剂反应，由所得醇制得的乙酸酯在NaIO 4存在下用RuCl 3 · x H 2 O处理后进行双键裂解，生成乙酰氧基二酸。然后用LiOH水解得到羟基二酸。

  DOI：

  10.1016/j.tetlet.2007.03.053

文献信息

• Novel polyhydroxyalkanoate, method of producing the same, charge controlling agent containing polyhydroxyalkanaote, toner binder and toner, and image formation method and image forming apparatus using toner
  申请人：——

  公开号：US20040005290A1

  公开（公告）日：2004-01-08

  Provided is a polyhydroxyalkanoate containing in a molecule thereof one or more units each selected from the group consisting of the following formulae (1), (2), (3) and (4): 1 wherein R 1 is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH 3 and OC 2 H 5 ; A 1 represents a substituted or unsubstituted aliphatic hydrocarbon structure; m is an integer selected from 0 to 7; and in the case where there exists a plurality of units, R 1 , A 1 and m represent the above described definements independently for each unit, 2 wherein R 6 is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH 3 and OC 2 H 5 ; J 6 represents a substituted or unsubstituted aliphatic hydrocarbon structure; n is an integer selected from 0 to 7; r is an integer selected from 1 to 500; and in the case where there exists a plurality of units, R 6 , J 6 , n and r represent the above described definements independently for each unit, 3 wherein n represents an integer of 0 to 7; and in the case where a plurality of units exist in the same molecule, n in one unit can be different from that in aonther unit respectively, and 4 wherein m represents an integer of 0 to 7; R 1 ′ to R 5 ′ represent independently a hydrogen atom or a halogen atom; and in the case where there exists a plurality of units, m and R 1 ′ to R 5 ′ represent the above described definements independently for each unit.

  提供一种聚羟基脂肪酸酯，其中分子中含有一种或多种单元，每种单元都选自以下公式组成的群体：1其中R1选自OH、卤素原子、ONa、OK、OCH3和OC2H5的群体，A1表示取代或未取代的脂肪族碳氢结构，m为0到7之间的整数，在存在多个单元的情况下，R1、A1和m分别独立地表示上述定义；2其中R6选自OH、卤素原子、ONa、OK、OCH3和OC2H5的群体，J6表示取代或未取代的脂肪族碳氢结构，n为0到7之间的整数，r为1到500之间的整数，在存在多个单元的情况下，R6、J6、n和r分别独立地表示上述定义；3其中n表示0到7之间的整数，在同一分子中存在多个单元的情况下，一个单元中的n可以与另一个单元中的n不同；4其中m表示0到7之间的整数，R1'到R5'分别独立地表示氢原子或卤素原子，在存在多个单元的情况下，m和R1'到R5'分别独立地表示上述定义。
• Novel polyhydroxyalkanoate, method of producing the same, charge controlling agent containing polyhydroxyalkanoate, toner binder and toner, and image formation method and image forming apparatus using toner
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1340777A1

  公开（公告）日：2003-09-03

  Provided is a polyhydroxyalkanoate containing in a molecule thereof one or more units each selected from the group consisting of the following formulae (1), (2), (3) and (4):    wherein R1 is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH3 and OC2H5; A1 represents a substituted or unsubstituted aliphatic hydrocarbon structure; m is an integer selected from 0 to 7; and in the case where there exists a plurality of units, R1, A1 and m represent the above described definements independently for each unit,    wherein R6 is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH3 and OC2H5; J6 represents a substituted or unsubstituted aliphatic hydrocarbon structure; n is an integer selected from 0 to 7; r is an integer selected from 1 to 500; and in the case where there exists a plurality of units, R6, J6, n and r represent the above described definements independently for each unit,    wherein n represents an integer of 0 to 7; and in the case where a plurality of units exist in the same molecule, n in one unit can be different from that in aonther unit respectively, and    wherein m represents an integer of 0 to 7; R1' to R5' represent independently a hydrogen atom or a halogen atom; and in the case where there exists a plurality of units, m and R1' to R5' represent the above described definements independently for each unit.

  本发明提供了一种聚羟基烷酸酯，其分子中含有一个或多个单元，每个单元均选自下式 (1)、(2)、(3) 和 (4) 所组成的组： 其中 R1 选自 OH、卤素原子、ONa、OK、OCH3 和 OC2H5 所组成的组；A1 代表取代或未取代的脂族烃结构；m 是选自 0 至 7 的整数；在存在多个单元的情况下，R1、A1 和 m 分别代表每个单元的上述定义、 其中 R6 选自由 OH、卤素原子、ONa、OK、OCH3 和 OC2H5 组成的组；J6 代表取代或未取代的脂族烃结构；n 是选自 0 至 7 的整数；r 是选自 1 至 500 的整数；在存在多个单元的情况下，R6、J6、n 和 r 对每个单元独立地代表上述定义、 其中 n 代表 0 至 7 的整数；在同一分子中存在多个单元的情况下，一个单元中的 n 可以分别不同于另一个单元中的 n，以及 其中 m 代表 0 至 7 的整数；R1' 至 R5' 独立地代表氢原子或卤素原子；在存在多个单元的情况下，m 和 R1' 至 R5' 独立地代表每个单元的上述定义。
• ALIPHATIC POLYESTER WITH HIGH ELONGATION
  申请人：Chang Chun Plastics Co., Ltd.

  公开号：EP3845580A1

  公开（公告）日：2021-07-07

  An aliphatic polyester is provided. The aliphatic polyester comprises: a first structural unit represented by -[-(CO)-R1-(CO)-]-, wherein R1 is absent or a C1 to C40 aliphatic hydrocarbyl; a second structural unit represented by -[-O-R2-O-]-, wherein R2 is a C1 to C10 aliphatic hydrocarbyl; and a third structural unit derived from a first cross-linking agent, wherein the first cross-linking agent has three reactive functional groups, wherein at least one reactive functional group is a secondary or tertiary hydroxyl, with the proviso that the first cross-linking agent is not malic acid.

  提供一种脂肪族聚酯。脂肪族聚酯包括 由-[-(CO)-R1-(CO)-]-代表的第一结构单元，其中 R1 不存在或为 C1 至 C40 脂肪族烃基； 由-[-O-R2-O-]-代表的第二结构单元，其中 R2 是 C1 至 C10 脂肪族烃基；以及 衍生自第一交联剂的第三结构单元，其中第一交联剂具有三个活性官能团，其中至少一个活性官能团是仲羟基或叔羟基，但第一交联剂不是苹果酸。
• Methods and systems for determining autism spectrum disorder risk
  申请人：Laboratory Corporation of America Holdings

  公开号：US10041932B2

  公开（公告）日：2018-08-07

  In certain embodiments, the invention stems from the discovery that analysis of population distribution curves of metabolite levels in blood can be used to facilitate predicting risk of autism spectrum disorder (ASD) and/or to differentiate between ASD and non-ASD developmental delay (DD) in a subject. In certain aspects, information from assessment of the presence, absence, and/or direction (upper or lower) of a tail effect in a metabolite distribution curve is utilized to predict risk of ASD and/or to differentiate between ASD and DD.

  在某些实施方案中，本发明源于发现血液中代谢物水平的群体分布曲线分析可用于促进预测自闭症谱系障碍（ASD）的风险和/或区分受试者的自闭症谱系障碍和非自闭症谱系障碍发育迟缓（DD）。在某些方面，评估代谢物分布曲线中尾部效应的存在、不存在和/或方向（上部或下部）的信息可用于预测 ASD 的风险和/或区分 ASD 和 DD。
• Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
  申请人：Metabolon, Inc.

  公开号：US10267777B2

  公开（公告）日：2019-04-23

  Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

  本文描述了对个体受试者进行小分子生化分析的方法，以诊断疾病或失调，促进疾病或失调的诊断，和/或确定个体受试者罹患疾病或失调的风险增加。确定个体受试者样本中存在的小分子的异常水平，并根据确定的异常水平获得与个体受试者相关的诊断信息。所获得的诊断信息包括：至少一个生化途径的鉴定，该生化途径与所鉴定的具有异常水平的小分子子集相关；至少一种疾病或紊乱的鉴定，该疾病或紊乱与所鉴定的具有异常水平的小分子子集相关；至少一种推荐的后续检测的鉴定，该检测与所鉴定的具有异常水平的小分子子集相关。