| 1079083-84-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1079083-84-3
• 化学式: C₂₇H₃₀ClNO₆
• 分子量: 499.991
• InChiKey: QBJJBEXJEJJFLX-SEFGFODJSA-N

反应信息

• 作为反应物：
  描述：

  、 5-羧基四甲基罗丹明琥珀酰亚胺酯 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以96%的产率得到5-(4-((4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenoxy)methyl)benzylcarbamoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)benzoate
  参考文献：
  名称：

  Design and synthesis of fluorescent SGLT2 inhibitors

  摘要：

  The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.036
• 作为产物：
  描述：

  在 盐酸 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of fluorescent SGLT2 inhibitors

  摘要：

  The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.036