(1R,23R,26R,27S)-27-hydroxy-3-oxo-24,29-dioxa-2,4,6,12,15,21-hexazaheptacyclo[24.2.1.02,23.05,22.07,20.08,13.014,19]nonacosa-5,7(20),8(13),9,11,14(19),15,17,21-nonaene-11,16-dicarboxylic acid | 1417202-87-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1R,23R,26R,27S)-27-hydroxy-3-oxo-24,29-dioxa-2,4,6,12,15,21-hexazaheptacyclo[24.2.1.02,23.05,22.07,20.08,13.014,19]nonacosa-5,7(20),8(13),9,11,14(19),15,17,21-nonaene-11,16-dicarboxylic acid
• CAS: 1417202-87-9
• 化学式: C₂₃H₁₆N₆O₈
• 分子量: 504.415
• InChiKey: MPPZZBKWEWFXHO-WLYVCJMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  37
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  197
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  新铜试剂 在 硫酸 、 水 、 硝酸 、 potassium bromide 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 5.0h， 生成 (1R,23R,26R,27S)-27-hydroxy-3-oxo-24,29-dioxa-2,4,6,12,15,21-hexazaheptacyclo[24.2.1.02,23.05,22.07,20.08,13.014,19]nonacosa-5,7(20),8(13),9,11,14(19),15,17,21-nonaene-11,16-dicarboxylic acid
  参考文献：
  名称：

  Rigid 5′-6-locked phenanthroline-derived nucleosides chelated to ruthenium and europium ions

  摘要：

  We describe complexes of ruthenium and europium with rigid, 5'-6-locked 1,10-phenanthroline-containing nucleosides. Both nucleosides were synthesized from condensation of 5-amino-2'-deoxycytidine with the corresponding diketone. The ruthenium nucleoside displayed fluorescence characteristic of polypyridine ruthenium complexes with a maximum at 616 nm and a quantum yield of 0.011. Binding of europium to the 1,10-phenanthroline-2,9-diacid moiety of the lanthanide binding nucleoside showed formation of a 1: 1 complex with emission at 570-630 nm, whose emission was enhanced by addition of two phenanthroline ligands. The lanthanide-binding nucleoside was incorporated into DNA oligonucleotides and shown to selectively bind one equivalent of europium ions. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.104