1-benzyl-4-(3-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one | 1337994-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1-benzyl-4-(3-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
• CAS: 1337994-24-7
• 化学式: C₂₂H₁₇ClN₂O
• 分子量: 360.843
• InChiKey: YRPNBCFYKUMGHN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-benzyl-4-(3-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one 在 (3R,5S)-5-(hydroxydiphenylmethyl)-1-picolinoylpyrrolidin-3-yl pivalate 、 三氯硅烷 作用下， 以 1,2-二氯乙烷 为溶剂， 以98%的产率得到1-benzyl-4-(3-chlorophenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one
  参考文献：
  名称：

  Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation

  摘要：

  Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product 3n has been determined as S by X-ray crystallographic analysis.

  DOI：

  10.1021/jo201334n
• 作为产物：
  描述：

  (E)-4-(3-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one 、 溴甲苯 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-benzyl-4-(3-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
  参考文献：
  名称：

  Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation

  摘要：

  Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product 3n has been determined as S by X-ray crystallographic analysis.

  DOI：

  10.1021/jo201334n