[Ru(N-hydroxyethylethylenediaminetriacetate)(NO)] | 221231-65-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [Ru(N-hydroxyethylethylenediaminetriacetate)(NO)]
• CAS: 221231-65-8
• 化学式: C₁₀H₁₅N₃O₈Ru
• 分子量: 406.314
• InChiKey: ZTSRBRJDFAGENB-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  Ru{N'-(2-hydroxyethyl)ethylenediamine-N,N,N'-triacetate}(H2O) 、 氧化亚氮 以 水 为溶剂， 生成 [Ru(N-hydroxyethylethylenediaminetriacetate)(NO)]
  参考文献：
  名称：

  [RuIII(medtra)(H2O)] (medtra=N-methylethylenediaminetriacetate) complex – A highly efficient NO inhibitor with low toxicity

  摘要：

  Stopped-flow kinetic measurements were used to compare the reactivities of [Ru(medtra)(H2O)] (medtra(3-) = N-methylethylenediaminetriacetate) (1) and [Ru(hedtra)(H2O)] (2) (hedtra(3-) = N-hydroxyethylethylenediaminetriacetate) with NO in aqueous solution at 15 degrees C, pH 7.2 (phosphate buffer). The measured second-order rate constants (3 x 10(3) and 6 x 10(4) m(-1) s(-1) for 1 and 2, respectively) are three to four order of magnitudes lower than that for the reaction between [Ru-III(edta)(H2O)](-) (3) with NO. However, NO scavenging studies of complexes 1-3, conducted by measuring the difference in nitrite production between treated and untreated murine macrophage cells, revealed that despite being less kinetically reactive toward NO, the [Ru(medtra)(H2O)] complex exhibited the highest NO scavenging ability and lowest toxicity of compounds 1-3. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2005.12.081