3-苄基-2-氯-6-甲基喹啉 | 918518-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-苄基-2-氯-6-甲基喹啉
• 英文名称: 3-Benzyl-2-chloro-6-methylquinoline
• CAS: 918518-70-4
• 化学式: C₁₇H₁₄ClN
• 分子量: 267.758
• InChiKey: PFGLVOOSOFWWNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-苄基-2-氯-6-甲基喹啉 在 硫脲 、 氢氧化钾 、 乙醇 、 水 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以95%的产率得到3-苄基-6-甲基-1H-喹啉-2-硫酮
  参考文献：
  名称：

  WO2007/436

  摘要：

  公开号：
• 作为产物：
  描述：

  3-phenyl-N-(p-tolyl)propanamide 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 生成 3-苄基-2-氯-6-甲基喹啉
  参考文献：
  名称：

  WO2007/14885

  摘要：

  公开号：

文献信息

• ANTIBACTERIAL QUINOLINE DERIVATIVES
  申请人：Janssen Pharmaceutica NV

  公开号：EP1912948B1

  公开（公告）日：2015-09-09
• Antibacterial Quinoline Derivatives
  申请人：Guillemont Jerome Emile Georges

  公开号：US20080182855A1

  公开（公告）日：2008-07-31

  The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum . Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.
• Quinoline Derivatives as Antibacterial Agents
  申请人：Andries Koenraad Jozef Lodewijk Marcel

  公开号：US20100204270A1

  公开（公告）日：2010-08-12

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof. Several of these compounds are also claimed as such. Further the combination of the above compounds with other antibacterial agents is described
• QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：ANDRIES Koenraad Jozef Lodewijk Marcel

  公开号：US20130030017A1

  公开（公告）日：2013-01-31

  Method of treating a bacterial infection other than a Mycobacterial infection, using a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein the substituents R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are as defined.
• US7915292B2
  申请人：——

  公开号：US7915292B2

  公开（公告）日：2011-03-29