| 859510-82-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 859510-82-0
• 化学式: C₈₈H₁₅₆O₂₃P₂
• 分子量: 1644.14
• InChiKey: COGKFQMWVIZEMP-RHANXBEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  23.16
• 重原子数：
  113.0
• 可旋转键数：
  80.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  243.65
• 氢给体数：
  0.0
• 氢受体数：
  23.0

反应信息

• 作为反应物：
  描述：

  在 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以430 mg的产率得到diallylphosphono 4-O-allyoxycarbonyl-2-O-[(R)-3-(allyloxycarbonyloxy)tetradecyl]-3-O-dodecyl-6-O-{4-O-diallylphosphono-3-O-[(R)-3-(methoxy)decyl]-6-O-methyl-2-O-[(Z)-11-(octadecenoyl)]-β-D-glucopyranosyl}-α,β-D-glucopyranoside
  参考文献：
  名称：

  Syntheses of glucose derivatives of E5564-related compounds and their LPS-antagonistic activities

  摘要：

  Glucose analogues 6, 12, 17b, 19a, and 19b of E5564 were synthesized, and their LPS-antagonistic activities were measured. The antagonistic activities (IC50) On LPS-induced TNF alpha production of these five compounds toward human whole blood were 72.8, 3.0, 0.9, 7.5, and 1.4 nM, respectively. Inhibitory doses (ID50) of compounds 12, 17b, 19a, and 19b on TNF alpha. production induced by co-injection of galactosamine and LPS in C3H/HeN mice in vivo were measured. The values of these compounds were 0.9, ND (not determined), 1.6, and 0.9 mg/kg, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2006.02.023
• 作为产物：
  描述：

  4-O-allyoxycarbonyl-2-O-[(R)-3-(allyloxycarbonyloxy)tetradecyl]-3-O-dodecyl-6-O-{4-O-diallylphosphono-3-O-[(R)-3-(methoxy)decyl]-6-O-methyl-2-O-[(Z)-11-(octadecenoyl)]-β-D-glucopyranosyl}-D-glucopyranose 、 己二烯 N,N-二异丙基亚磷酰胺 在 四氮唑 、 sodium sulfate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Syntheses of glucose derivatives of E5564-related compounds and their LPS-antagonistic activities

  摘要：

  Glucose analogues 6, 12, 17b, 19a, and 19b of E5564 were synthesized, and their LPS-antagonistic activities were measured. The antagonistic activities (IC50) On LPS-induced TNF alpha production of these five compounds toward human whole blood were 72.8, 3.0, 0.9, 7.5, and 1.4 nM, respectively. Inhibitory doses (ID50) of compounds 12, 17b, 19a, and 19b on TNF alpha. production induced by co-injection of galactosamine and LPS in C3H/HeN mice in vivo were measured. The values of these compounds were 0.9, ND (not determined), 1.6, and 0.9 mg/kg, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2006.02.023

文献信息

• EP1702926
  申请人：——

  公开号：——

  公开（公告）日：——