2-hydroxy-3-(N-methylanilino)propiophenone | 108649-58-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-3-(N-methylanilino)propiophenone
• 英文别名: 1-(2-hydroxyphenyl)-3-(N-methylanilino)propan-1-one
• CAS: 108649-58-7
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: MHSHIMSTKHZICR-UHFFFAOYSA-N

物化性质

• 沸点：
  413.1±25.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-3-(N-methylanilino)propiophenone 在 sodium hydride 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 N-[(Z)-3-imidazol-1-yl-3-[2-(2-methylpropoxy)phenyl]prop-2-enyl]-N-methylaniline
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014
• 作为产物：
  描述：

  3-(dimethylamino)-1-(2-hydroxyphenyl)propan-1-one hydrochloride 、 N-甲基苯胺 以 乙醇 、 水 为溶剂， 反应 4.0h， 以37%的产率得到2-hydroxy-3-(N-methylanilino)propiophenone
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014

文献信息

• OGATA, MASARU;MATSUMOTO, HIROSHI;SHIMIZU, SUMIO;KIDA, SHIRO;SHIRO, MOTOO;+, J. MED. CHEM., 30,(1987) N 8, 1348-1354
  作者：OGATA, MASARU、MATSUMOTO, HIROSHI、SHIMIZU, SUMIO、KIDA, SHIRO、SHIRO, MOTOO、+

  DOI：——

  日期：——