ethyl 2-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyacetate | 220689-80-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyacetate
• CAS: 220689-80-5
• 化学式: C₃₈H₄₂O₈
• 分子量: 626.747
• InChiKey: ATBZYPHOOSEQJQ-MQPLVFOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  46
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl 2-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyacetate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以72%的产率得到2-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyacetic acid
  参考文献：
  名称：

  An Access to Glycoconjugate Libraries through Multicomponent Reactions

  摘要：

  Four-component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per-O-benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.

  DOI：

  10.1002/(sici)1521-3773(19981231)37:24<3436::aid-anie3436>3.0.co;2-z
• 作为产物：
  描述：

  乙醇酸乙酯 、 2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl trichloroacetimidate 在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 以82%的产率得到ethyl 2-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyacetate
  参考文献：
  名称：

  An Access to Glycoconjugate Libraries through Multicomponent Reactions

  摘要：

  Four-component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per-O-benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.

  DOI：

  10.1002/(sici)1521-3773(19981231)37:24<3436::aid-anie3436>3.0.co;2-z