2,3-Dimethyl-7-methoxy-chinolin | 30160-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,3-Dimethyl-7-methoxy-chinolin
• 英文别名: 7-Methoxy-2,3-dimethylchinolin；7-methoxy-2,3-dimethyl-quinoline；7-Methoxy-2,3-dimethylquinoline
• CAS: 30160-01-1
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: UQSIDNNGBUIAFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• OXAZOLIDINONE COMPOUNDS, AND COMPOSITIONS AND METHODS RELATED THERETO
  申请人：Cano Montserrat

  公开号：US20090062266A1

  公开（公告）日：2009-03-05

  The invention provides new oxazolidinone compounds of formula (I) wherein A is certain heterocycles optionally substituted; R 1 , R 2 , R 3 and R 4 are independently selected from —H and halogen; X is selected from O, S, NR 9 and CR 9 R 10 ; R 9 and R 10 having different meanings; Y is selected from O, S, SO, SO 2 , NO, NR 12 and CR 12 R 13 ; R 12 and R 13 having different meanings. It also provides different processes for the preparation of such compounds. Oxazolidinone compounds of formula (I) are active against Gram-positive and some Gram-negative human and veterinary pathogens with a weak monoamine oxidase (MAO) inhibitory activity. They are useful for the treatment of bacterial infections.

  该发明提供了具有以下结构式（I）的新的噁唑烷酮化合物，其中A是某些杂环，可以选择性地被取代；R1、R2、R3和R4独立地选自-H和卤素；X选自O、S、NR9和CR9R10；R9和R10具有不同的含义；Y选自O、S、SO、SO2、NO、NR12和CR12R13；R12和R13具有不同的含义。它还提供了制备这些化合物的不同方法。结构式（I）的噁唑烷酮化合物对革兰氏阳性和一些革兰氏阴性人类和兽医病原体具有较弱的单胺氧化酶（MAO）抑制活性。它们可用于治疗细菌感染。
• Aza- and polyazanthranyl amides and their use as medicaments
  申请人：SEIDELMANN Dieter

  公开号：US20110071165A1

  公开（公告）日：2011-03-24

  Aza- and polyazanthranyl amides and their use as medicaments in the treatment of diseases caused by persistent angiogenesis are described, as well as the intermediates used in the preparation of the aza- and polyazanthranyl amides.

  本文描述了Aza-和polyazanthranyl酰胺及其用作治疗由持续血管生成引起的疾病的药物，以及制备Aza-和polyazanthranyl酰胺所使用的中间体。
• OXAZOLIDINONE DERIVATIVES AND USE THEREOF AS ANTIBIOTICS
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1902050B1

  公开（公告）日：2009-09-09
• US7429592B2
  申请人：——

  公开号：US7429592B2

  公开（公告）日：2008-09-30
• US7759351B2
  申请人：——

  公开号：US7759351B2

  公开（公告）日：2010-07-20