Piperidine-1,4-dicarboxylic acid 4-ethyl ester 1-[(1R,2R)-2-((2R,3R,4R,5S,6S)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl] ester | 191939-17-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Piperidine-1,4-dicarboxylic acid 4-ethyl ester 1-[(1R,2R)-2-((2R,3R,4R,5S,6S)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl] ester
• CAS: 191939-17-0
• 化学式: C₂₉H₄₃NO₁₄
• 分子量: 629.659
• InChiKey: BLXUGHGFTLYHEQ-UWWJVFONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  44.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  179.5
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  Piperidine-1,4-dicarboxylic acid 4-ethyl ester 1-[(1R,2R)-2-((2R,3R,4R,5S,6S)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl] ester 在 sodium hydroxide 、 sodium methylate 作用下， 生成 Piperidine-1,4-dicarboxylic acid mono-[(1R,2R)-2-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl] ester
  参考文献：
  名称：

  PIPERIDINE CARBOXYLIC ACID DERIVATIVES AS SIALYL LEWIS X MIMETICS

  摘要：

  Four piperidine carboxylic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays, in viva and in a reperfusion model. Compound 7 showed strong inhibition of leukocyte adhesion in rats and a poweful decrease of the incidence of arrhythmias in a reperfusion model in isolated rabbit hearts. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00213-8
• 作为产物：
  描述：

  哌啶-4-甲酸乙酯 在 三氟甲磺酸三甲基硅酯 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 Piperidine-1,4-dicarboxylic acid 4-ethyl ester 1-[(1R,2R)-2-((2R,3R,4R,5S,6S)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl] ester
  参考文献：
  名称：

  PIPERIDINE CARBOXYLIC ACID DERIVATIVES AS SIALYL LEWIS X MIMETICS

  摘要：

  Four piperidine carboxylic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays, in viva and in a reperfusion model. Compound 7 showed strong inhibition of leukocyte adhesion in rats and a poweful decrease of the incidence of arrhythmias in a reperfusion model in isolated rabbit hearts. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00213-8