4-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-thiazol-4-yl}-3-(6-methoxy-pyridin-3-yl)-butyric acid ethyl ester | 877398-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-thiazol-4-yl}-3-(6-methoxy-pyridin-3-yl)-butyric acid ethyl ester
• CAS: 877398-91-9
• 化学式: C₂₅H₄₀N₂O₄SSi
• 分子量: 492.755
• InChiKey: RPHRPTYYRBMZLU-UHFFFAOYSA-N

物化性质

• 沸点：
  545.5±50.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  33.0
• 可旋转键数：
  13.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  70.54
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  4-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-thiazol-4-yl}-3-(6-methoxy-pyridin-3-yl)-butyric acid ethyl ester 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 ethyl 4-[2-(4-hydroxybutyl)-1,3-thiazol-4-yl]-3-(6-methoxypyridin-3-yl)butanoate
  参考文献：
  名称：

  Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

  摘要：

  We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(V)beta(3) and show selectivity relative to the other integrins, such as alpha(IIB)beta(3) and alpha(V)beta(6). These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.017
• 作为产物：
  描述：

  3-(6-methoxypyridin-3-yl)pentanedioic acid 在 盐酸 、 草酰氯 、 乙酸酐 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 生成 4-{2-[4-(tert-Butyl-dimethyl-silanyloxy)-butyl]-thiazol-4-yl}-3-(6-methoxy-pyridin-3-yl)-butyric acid ethyl ester
  参考文献：
  名称：

  Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

  摘要：

  We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(V)beta(3) and show selectivity relative to the other integrins, such as alpha(IIB)beta(3) and alpha(V)beta(6). These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.017