methyl 7-ethyl-2-methyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate | 1349689-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 7-ethyl-2-methyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
• CAS: 1349689-19-5
• 化学式: C₂₆H₂₇NO₃
• 分子量: 401.505
• InChiKey: CFGVSMCXBNOUBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酰乙酸甲酯 、 对苯基苯甲醛 、 5-乙基环己烷-1,3-二酮半水化合物 在 ammonium acetate 、 碘 作用下， 以 乙醇 为溶剂， 生成 methyl 7-ethyl-2-methyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
  参考文献：
  名称：

  Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling

  摘要：

  A medium-throughput murine embryonic stem cell (mESC)-based high-content screening of 17000 small molecules for cardiogenesis led to the identification of a b-annulated 1,4-dihydropyridine (1,4-DHP) that inhibited transforming growth factor beta (TGF beta)/Smad signaling by clearing the type II TGF beta receptor from the cell surface. Because this is an unprecedented mechanism of action, we explored the series' structure-activity relationship (SAR) based on TGF beta inhibition, and evaluated SAR aspects for cell-surface clearance of TGF beta receptor II (TGFBR2) and for biological activity in mESCs. We determined a pharmacophore and generated 1,4-DHPs with IC(50)s for TGF beta inhibition in the nanomolar range (e.g., compound. 28, 170 nM). Stereochemical consequences of a chiral center at the 4-position was evaluated, revealing 10- to 15-fold more potent TGF beta inhibition for the (+)- than the (-) enantiomer. This stereopreference was not observed for the low level inhibition against Activin A signaling and was reversed for effects on calcium handling in HL-1 cells.

  DOI：

  10.1021/jm301144g

文献信息

• COMPOUNDS FOR STEM CELL DIFFERENTIATION
  申请人：Mercola Mark

  公开号：US20110281356A1

  公开（公告）日：2011-11-17

  Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , R 6 , R 6′ , R 7 , R 7′ are as described herein.

  提供了用于干细胞分化的方法和小分子化合物。可以使用的化合物类别之一的示例由公式I所表示的化合物组成：或其药学上可接受的盐或溶剂，其中R1，R2，R3，R4，R5，R5'，R6，R6'，R7，R7'如本文所述。
• US9233926B2
  申请人：——

  公开号：US9233926B2

  公开（公告）日：2016-01-12
• [EN] COMPOUNDS FOR STEM CELL DIFFERENTIATION<br/>[FR] COMPOSÉS PERMETTANT DE DIFFÉRENCIER DES CELLULES SOUCHES
  申请人：SANFORD BURNHAM MED RES INST

  公开号：WO2012158568A1

  公开（公告）日：2012-11-22

  Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by compounds and enantiomerically pure isomer of Formula I: or a chirally pure stereoisomer, pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4, R5, R5', R6, R6', R7, R7' are as described herein.