| 1145724-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1145724-69-1
• 化学式: C₁₈H₁₉N₃O₃S
• 分子量: 357.433
• InChiKey: FYLYOWFKGLZPKC-UHFFFAOYSA-N

物化性质

• 沸点：
  580.6±50.0 °C(predicted)
• 密度：
  1.330±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  4-(3-Methoxyanilino)-6-methylsulfonylquinoline-3-carbonitrile 在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

  摘要：

  Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD.

  DOI：

  10.1016/j.bmcl.2009.01.045