1,4-bis(2,3,4-tri-O-acetyl-1-O-4-pentenyl-α-D-N-methyl-glucuronamido)benzene | 848590-93-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-bis(2,3,4-tri-O-acetyl-1-O-4-pentenyl-α-D-N-methyl-glucuronamido)benzene
• CAS: 848590-93-2
• 化学式: C₄₂H₅₆N₂O₁₈
• 分子量: 876.909
• InChiKey: QPIUGFIYGKAUMG-OADVPICFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  62.0
• 可旋转键数：
  20.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  235.34
• 氢给体数：
  0.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  1,4-bis(2,3,4-tri-O-acetyl-1-O-4-pentenyl-α-D-N-methyl-glucuronamido)benzene 在 Grubbs catalyst first generation 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 40.5h， 生成
  参考文献：
  名称：

  Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic

  摘要：

  Rigid macrocyclic scaffolds based on carbohydrates have potential for the display of recognition groups with defined 3D structure and may have application in bioorganic and supramolecular chemistry. A series of water soluble macrocyclic structures containing two saccharide units was synthesised by ring closing metathesis of allyl and pentenyl glycosides derived from glucuronic acid. The 3D structure of the constrained systems was explored by NMR and computational methods. CD spectra were also recorded. On the basis of experimental observations we suggest that the carbohydrate presentation is constrained into a U-shape for the smaller ring size but can access an S-shape arrangement in the larger macrocycle. As an extension it is shown that the larger macrocycle displayed phenomena similar to beta-cyclodextrin (beta-CD). The binding of 8-anilino-1-naphthalenesulfonate (ANS) to beta-CD is detectable by reversal of quenching of the ANS emission spectrum and a similar reversal of quenching was observed when this macrocycle was added to a solution of ANS; this was further supported by NMR. Furthermore molecular modelling suggests that the macrocyclic scaffolding has potential for the development of peptidomimetics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.020
• 作为产物：
  描述：

  [(2S,3R,4S,5S,6S)-3,5-diacetyloxy-2-pent-4-enoxy-6-[[4-[[(2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-pent-4-enoxyoxane-2-carbonyl]amino]phenyl]carbamoyl]oxan-4-yl] acetate 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以54%的产率得到1,4-bis(2,3,4-tri-O-acetyl-1-O-4-pentenyl-α-D-N-methyl-glucuronamido)benzene
  参考文献：
  名称：

  Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic

  摘要：

  Rigid macrocyclic scaffolds based on carbohydrates have potential for the display of recognition groups with defined 3D structure and may have application in bioorganic and supramolecular chemistry. A series of water soluble macrocyclic structures containing two saccharide units was synthesised by ring closing metathesis of allyl and pentenyl glycosides derived from glucuronic acid. The 3D structure of the constrained systems was explored by NMR and computational methods. CD spectra were also recorded. On the basis of experimental observations we suggest that the carbohydrate presentation is constrained into a U-shape for the smaller ring size but can access an S-shape arrangement in the larger macrocycle. As an extension it is shown that the larger macrocycle displayed phenomena similar to beta-cyclodextrin (beta-CD). The binding of 8-anilino-1-naphthalenesulfonate (ANS) to beta-CD is detectable by reversal of quenching of the ANS emission spectrum and a similar reversal of quenching was observed when this macrocycle was added to a solution of ANS; this was further supported by NMR. Furthermore molecular modelling suggests that the macrocyclic scaffolding has potential for the development of peptidomimetics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.020