1-[1-(4-Fluorophenyl)propyl]-3-[3-methoxy-4-(4-methylimidazol-1-yl)benzoyl]piperidin-2-one | 1186045-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[1-(4-Fluorophenyl)propyl]-3-[3-methoxy-4-(4-methylimidazol-1-yl)benzoyl]piperidin-2-one
• CAS: 1186045-91-9
• 化学式: C₂₆H₂₈FN₃O₃
• 分子量: 449.525
• InChiKey: RSEZQISQKRYRIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[1-(4-Fluorophenyl)propyl]-3-[3-methoxy-4-(4-methylimidazol-1-yl)benzoyl]piperidin-2-one 在 盐酸羟胺 、 potassium acetate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

  摘要：

  We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as gamma-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of gamma-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting A beta(42) production. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.012
• 作为产物：
  描述：

  C₂₆H₃₀FN₃O₃ 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-[1-(4-Fluorophenyl)propyl]-3-[3-methoxy-4-(4-methylimidazol-1-yl)benzoyl]piperidin-2-one
  参考文献：
  名称：

  Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

  摘要：

  We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as gamma-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of gamma-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting A beta(42) production. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.012

文献信息

• GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Huang Xianhai

  公开号：US20110027264A1

  公开（公告）日：2011-02-03

  This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

  本发明提供了一种新型化合物，其为γ-分泌酶调节剂。该化合物的化学式为：同时还揭示了使用式(I)的化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法。
• Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
  作者：Jun Qin、Pawan Dhondi、Xianhai Huang、Mihirbaran Mandal、Zhiqiang Zhao、Dmitri Pissarnitski、Wei Zhou、Robert Aslanian、Zhaoning Zhu、William Greenlee、John Clader、Lili Zhang、Mary Cohen-Williams、Nicholas Jones、Lynn Hyde、Anandan Palani

  DOI：10.1016/j.bmcl.2010.12.012

  日期：2011.1

  We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as gamma-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of gamma-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting A beta(42) production. (C) 2010 Elsevier Ltd. All rights reserved.