| 882172-42-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 882172-42-1
• 化学式: C₄₅H₅₆N₈O₇
• 分子量: 820.989
• InChiKey: DDQAOHGSDSPKEL-RCLBEZBBSA-N

反应信息

• 作为反应物：
  描述：

  在 10% palladium on barium sulfate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成 (R)-3-{(R)-3-[(S)-4-Guanidino-1-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-butylcarbamoyl]-4-phenyl-butyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005
• 作为产物：
  描述：

  (R)-1,2,3,6,11,11a-Hexahydro-pyrido[1,2-b]isoquinolin-4-one 在 N-甲基吗啉 、 盐酸 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 57.0h， 生成
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005