| 1561048-76-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1561048-76-7
• 化学式: C₃₃H₄₀O₇S
• 分子量: 580.742
• InChiKey: JWHJLIUVZUFOTJ-UCECOGJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.97
• 重原子数：
  41.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  75.61
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  溴甲苯 在 吡啶 、 ReOCl₃(SMe₂)(OPPh₃) 、 sodium hydride 、 二正丁基氧化锡 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 甲苯 、 mineral oil 为溶剂， 反应 27.67h， 生成
  参考文献：
  名称：

  Direct Synthesis of 2-Deoxy-β-Glycosides via Anomeric O-Alkylation with Secondary Electrophiles

  摘要：

  An approach for direct synthesis of biologically significant 2-deoxy-beta-glycosides has been developed via O-alkylation of a variety of 2-deoxy-sugar-derived anomeric alkoxides using challenging secondary triflates as electrophiles. It was found a free hydroxyl group at C3 of the 2-deoxy-sugar-derived lactols is required in order to achieve synthetically efficient yields. This method has also been applied to the convergent synthesis of a 2-deoxy-beta-tetrasaccharide.

  DOI：

  10.1021/ja4116956

文献信息

• Synthesis of the 2-deoxy trisaccharide glycal of antitumor antibiotics landomycins A and E
  作者：Xiaohua Li、Justin Woodward、Ali Hourani、Danyang Zhu、Sabrine Ayoub、Jianglong Zhu

  DOI：10.1016/j.carres.2016.04.031

  日期：2016.7

  Synthesis of the 2-deoxy trisaccharide glycal of antitumor antibiotics landomycins A and E has been described. The synthesis involves an anomeric O-alkylation for the synthesis of 2-deoxy beta-linked disaccharide, a tert-butyldimethylsilyl triflate-catalyzed alpha-selective L-rhodinosylation, and a lithium 4,4'-di-tert-butylbiphenyl-mediated reductive debenzylation and concomitant reductive lithiation-elimination

  已经描述了抗肿瘤抗生素兰霉素A和E的2-脱氧三糖糖基的合成。该合成涉及用于合成2-脱氧β-连接的二糖的异头O-烷基化，叔丁基二氟甲磺酸叔丁基二甲基甲硅烷基催化的α-选择性L-古丁糖基化和4,4'-二叔丁基联苯锂介导的还原反应脱苄基化和伴随的还原性锂化消除，以生产2-脱氧三糖。