| 949165-94-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 949165-94-0
• 化学式: C₄₄H₆₄N₆O₁₂
• 分子量: 869.025
• InChiKey: NNWIPSNMUZWGKZ-JSGDOJDWSA-N

反应信息

• 作为反应物：
  描述：

  在 双(三甲基硅烷基)氨基钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Novel tethers in ketolide antibiotics

  摘要：

  Novel macrolide antibiotics which contain a methylerie unit between two nitrogen atoms of carbarnate groups or between two nitrogen atoms of one carbarnate and one urea group were synthesized using the Curtius rearrangement. Such linkers were shown to be stable under physiological conditions, and the resulting ketolides show potent in vitro and in vivo activity against macrolide-resistant respiratory pathogens. The SAR of various heterocycles and linkers was established. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.018
• 作为产物：
  描述：

  喹喔啉-6-甲胺 、 生成
  参考文献：
  名称：

  Novel tethers in ketolide antibiotics

  摘要：

  Novel macrolide antibiotics which contain a methylerie unit between two nitrogen atoms of carbarnate groups or between two nitrogen atoms of one carbarnate and one urea group were synthesized using the Curtius rearrangement. Such linkers were shown to be stable under physiological conditions, and the resulting ketolides show potent in vitro and in vivo activity against macrolide-resistant respiratory pathogens. The SAR of various heterocycles and linkers was established. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.018