6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(2-methoxylphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline | 1026777-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(2-methoxylphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
• 英文别名: 6-[4-[N-(2-Dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(2-methoxyphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline；[3-methoxy-4-[5-[(2-methoxyanilino)methyl]-2,2,4-trimethyl-1H-quinolin-6-yl]phenyl] N-[2-(dimethylamino)ethyl]-N-methylcarbamate
• CAS: 1026777-94-5
• 化学式: C₃₃H₄₂N₄O₄
• 分子量: 558.721
• InChiKey: VGWMDZVQCBZWEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-(4-hydroxy-2-methoxyphenyl)-5-(2-methoxyphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquioline 在 4-二甲氨基吡啶 、 碳酸氢钠 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 9.5h， 生成 6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(2-methoxylphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
  参考文献：
  名称：

  GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP

  摘要：

  公开号：

  EP2319835B1

文献信息

• NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLAMINO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS
  申请人：Matsuda Mamoru

  公开号：US20090298827A1

  公开（公告）日：2009-12-03

  The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator. The R 1 represents a hydrogen atom or a lower alkyl group; R 2 represents a hydrogen atom or a lower alkyl group; R 3 and R 4 may be the same or different and represents a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom or a lower alkyl group; R 6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X represents —C(O)—, —C(O)NR 8 —, —S(O) 2 — and the like; R 7 and/or R 8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; and P represents 0, 1, 2 or 3.

  通式（1）及其盐对于糖皮质激素受体调节剂很有用。其中，R1代表氢原子或较低烷基；R2代表氢原子或较低烷基；R3和R4可以相同也可以不同，代表氢原子或较低烷基；R5代表氢原子或较低烷基；R6代表卤原子、较低烷基、羟基、较低烷氧基、硝基或氰基；X代表—C（O）—，—C（O）NR8—，—S（O）2—等；R7和/或R8可以相同也可以不同，代表氢原子、较低烷基（可能具有取代基）、芳基（可能具有取代基）、杂环基（可能具有取代基）、较低烷氧基（可能具有取代基）等；Y代表较低烷基烯基；P代表0、1、2或3。
• Method for preventing or treating a disease related to the glucocorticoid receptor
  申请人：MATSUDA Mamoru

  公开号：US20110275632A1

  公开（公告）日：2011-11-10

  A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound.

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，涉及给予一种1,2-二氢喹啉化合物的药理有效剂量。
• 1,2-dihydroquinoline derivative having substituted phenylamino lower alkyl group and ester-introduced phenyl group as substituents
  申请人：Santen Pharmaceutical Co., Ltd.

  公开号：US08008498B2

  公开（公告）日：2011-08-30

  The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator. The R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represents a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X represents —C(O)—, —C(O)NR8—, —S(O)2— and the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; and P represents 0, 1, 2 or 3.

  通式（1）所代表的化合物及其盐对于糖皮质激素受体调节剂很有用。其中，R1代表氢原子或较低的烷基；R2代表氢原子或较低的烷基；R3和R4可以相同也可以不同，代表氢原子或较低的烷基；R5代表氢原子或较低的烷基；R6代表卤原子、较低的烷基、羟基、较低的烷氧基、硝基或氰基；X代表—C（O）—、—C（O）NR8—、—S（O）2—等；R7和/或R8可以相同也可以不同，代表氢原子、较低的烷基（可能有取代基）、芳基（可能有取代基）、杂环基（可能有取代基）、较低的烷氧基（可能有取代基）等；Y代表较低的烷基；P代表0、1、2或3。
• GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING SUBSTITUTED OXY GROUP
  申请人：Kato Masatomo

  公开号：US20110118260A1

  公开（公告）日：2011-05-19

  The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt thereof and novel pharmacological effects of the glucocorticoid receptor agonists. In the formula (1), R 1 represents formula (2a), (3a), (4a) or (5a); R 2 represents —(CO)—R8, —(CO)O—R9, or the like; R 2 —O— is substituted at the 4- or -5-position of benzene ring A; R 3 represents a lower alkyl group; R 4 , R 5 , R 6 or R 7 represents a halogen atom, a lower alkyl group which may have a substituent, or the like; m, n, p or q represents 0, 1 or the like; R 8 , R 9 or the like represents a lower alkyl group which may have a substituent, a lower alkenyl group, or the like.

  本发明涉及由式（1）表示的化合物组成的糖皮质激素受体激动剂或其盐，并且涉及糖皮质激素受体激动剂的新的药理作用。在式（1）中，R1表示式（2a）、（3a）、（4a）或（5a）；R2表示—（CO）—R8、—（CO）O—R9或类似物；R2—O—在苯环A的4-或5-位上被取代；R3表示较低的烷基；R4、R5、R6或R7表示卤原子、可能具有取代基的较低的烷基或类似物；m、n、p或q表示0、1或类似物；R8、R9或类似物表示可能具有取代基的较低的烷基、较低的烯基或类似物。
• Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivatives having substituted oxy group
  申请人：Kato Masatomo

  公开号：US08426406B2

  公开（公告）日：2013-04-23

  The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt thereof and novel pharmacological effects of the glucocorticoid receptor agonists. In the formula (1), R1 represents formula (2a), (3a), (4a) or (5a); R2 represents —(CO)—R8, —(CO)O—R9, or the like; R2—O— is substituted at the 4- or -5-position of benzene ring A; R3 represents a lower alkyl group; R4, R5, R6 or R7 represents a halogen atom, a lower alkyl group which may have a substituent, or the like; m, n, p or q represents 0, 1 or the like; R8, R9 or the like represents a lower alkyl group which may have a substituent, a lower alkenyl group, or the like.

  本发明涉及一种由式（1）所表示的化合物组成的糖皮质激素受体激动剂或其盐，并且涉及所述糖皮质激素受体激动剂的新的药理作用。在式（1）中，R1表示式（2a）、（3a）、（4a）或（5a）；R2表示—（CO）—R8、—（CO）O—R9或类似物；R2—O—在苯环A的4-或5-位被取代；R3表示较低的烷基；R4、R5、R6或R7表示卤原子、可以有取代基的较低烷基或类似物；m、n、p或q表示0、1或类似物；R8、R9或类似物表示可以有取代基的较低烷基、较低烯基或类似物。