| 1456889-19-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1456889-19-2
• 化学式: C₂₇H₅₀O₆Si₂
• 分子量: 526.861
• InChiKey: HDNSMCMECUVBRM-MBWGTIHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  35.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 甲醇 、 4-甲基苯磺酸吡啶 、 三乙胺 作用下， 反应 2.0h， 以13 mg的产率得到(S)-1-((4aR,6S,7R,8aS)-2,2-di-tert-butyl-7-hydroxyhexahydropyrano[3,2-d][1,3,2]dioxasilin-6-yl)penta-3,4-dien-2-yl acetate
  参考文献：
  名称：

  Synthesis of fused tetrahydropyrans by hydroalkoxylation of δ-hydroxy allenes

  摘要：

  Fused tetrahydropyrans were synthesized by silver(l)- and mercury(II)-mediated intramolecular hydroalkoxylations of delta-hydroxy allenes installed on a tetrahydropyran template. Cyclization of simple allenes was promoted by silver perchlorate to afford vinyl-substituted trans-fused bis-tetrahydropyrans, whereas cyclization of methyl-substituted allenes at the internal allenic carbon atom was achieved more effectively with a catalytic amount of mercuric triflate rather than with silver salts. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.08.026
• 作为产物：
  描述：

  (4aR,6S,7R,8aS)-2,2-di-tert-butyl-7-((triethylsilyl)oxy)-6-vinylhexahydropyrano[3,2-d][1,3,2]dioxasiline 在 吡啶 、 chromium dichloride 、 甲醇 、 4-二甲氨基吡啶 、 双氧水 、 sodium methylate 、 potassium carbonate 、 戴斯-马丁氧化剂 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 25.25h， 生成
  参考文献：
  名称：

  Synthesis of fused tetrahydropyrans by hydroalkoxylation of δ-hydroxy allenes

  摘要：

  Fused tetrahydropyrans were synthesized by silver(l)- and mercury(II)-mediated intramolecular hydroalkoxylations of delta-hydroxy allenes installed on a tetrahydropyran template. Cyclization of simple allenes was promoted by silver perchlorate to afford vinyl-substituted trans-fused bis-tetrahydropyrans, whereas cyclization of methyl-substituted allenes at the internal allenic carbon atom was achieved more effectively with a catalytic amount of mercuric triflate rather than with silver salts. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.08.026